Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2004

Cord blood leptin, insulin, C-peptide, IGF-1 and IGF-2 levels in relation to echocardiographic measurements in infants of diabetic mothers: preliminary report

Wojciech Wnuk, Grażyna Hnatyszyn, Halina Konefał, Grażyna Dawid, Maria Beata Czeszyńska, Elżbieta Pankiewicz, Anita Horodnicka-Józwa

Med Sci Monit 2004; 10(2): 28-32 :: ID: 11855


Background: One of the well-known disturbances in IDM is hypertrophic cardiomyopathy. Insulin and IGF-1, and IGF-2 are known to be important growth promoters in the variety of tissues. Increased cord levels of these factors are frequent findings in the infants of diabetic mothers (IDM). Leptin also may be involved in the increased body mass and accumulation of adipose tissue. Objective: The aim of the study was to evaluate whether there is an association between morphological heart parameters and cardiac function estimated during echocardiographic examination in infants of the diabetic mothers and cord blood leptin, insulin, C-peptide, IGF-1 and IGF-2 concentration at birth.Material/Methods: Among 28 infants of gestational diabetic mothers (16 AGA, 12 LGA) echocardiography measurements were performed according to the recommendation of American Society of Echocardiography. Venous cord blood samples were collected at delivery. Leptin, insulin, and C-peptide levels were measured using specific RIAs, while IGF-1 and IGF-2 levels by using specificELISA.Results: Echocardiography measurements were within the normal range in most of our examined IDM. IVSd hypertrophy was found in 5 IDM, 3 of them AGA and 2 LGA. In 6 (21.4 %) an increase of SF >40% was noticed; half of them was LGA. A significant positive correlation between SF% and IGF-1 and IGF-2 levels was found. No significant correlation was noticed between all analyzed echocardiography parameters and insulin, and C-peptide levels.Conclusions: There is an association between dynamic function of the left ventricle and cord blood IGF-1 and IGF-2 levels in IDM.

Keywords: infants of diabetic mothers (IDM), IGF-1, IGF-2, cord blood, Leptin, Insulin, hypertrophic cardiomyopathy



01 February 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939580

Med Sci Monit 2023; 29:e939580


19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

10 December 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit 2022; 28:e938647

In Press

02 Feb 2023 : Clinical Research  

Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938672  

02 Feb 2023 : Database Analysis  

Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based...

Med Sci Monit In Press; DOI: 10.12659/MSM.938785  

01 Feb 2023 : Clinical Research  

Comparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...

Med Sci Monit In Press; DOI: 10.12659/MSM.939084  

31 Jan 2023 : Clinical Research  

Balloon Dilation Eustachian Tuboplasty Combined with Tympanotomy Tube Insertion for Treatment of Refractory...

Med Sci Monit In Press; DOI: 10.12659/MSM.938879  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750