27 August 2003
Med Sci Monit 2003; 9(8): BR302-309 :: ID: 13090
Background:This investigation studied whether low frequency electrical impulses (EI) induce or prevent development of new atherosclerotic plaque in previously diseased vessels.Material/Methods:In all rabbits, an electrode was sutured to the left psoas major muscle close to the upper part of the abdominal aorta (AA), and a pacemaker was implanted on the opposite side of the AA just below diaphragm. Group 1 received a high cholesterol diet (HCD) to induce atherosclerosis but no EI (control). Euthanasia followed after 3 weeks (series I), 8 weeks (series II) and 11 weeks (series III) of HCD. In series IV animals received HCD alone for 3 weeks then EI was added to the HCD for another 8 weeks (weeks 4–11) at a rate of 30 impulses per minute (IPM) at 3V. Euthanasia followed after 11 weeks. Atherosclerotic thickness grades were assigned using a 0 (low) to 4 (high) grading system, and the surface area involved in disease was calculated.Results:In control rabbits, after 11 weeks of HCD atherosclerotic thickness grade in lower abdominal aorta was 1.68I0.25. In rabbits exposed to EI (30 IPM at 3V) this grade was 0.5±0.37 (p
Keywords: Aorta - cytology, Aorta - pathology, Arteriosclerosis - pathology, Arteriosclerosis - therapy, Cholesterol, Dietary - administration & dosage, Cholesterol, Dietary - adverse effects, Electric Stimulation, Rabbits
01 November 2023 : EditorialEditorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared
Med Sci Monit 2023; 29:e942960
28 Nov 2023 : Clinical ResearchImpact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...
Med Sci Monit In Press; DOI: 10.12659/MSM.942122
28 Nov 2023 : Clinical ResearchLong-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...
Med Sci Monit In Press; DOI: 10.12659/MSM.943031
27 Nov 2023 : Clinical ResearchComparison of Outcomes from Emergency Admissions to a Major Trauma Center in Turkey of 1646 Elderly Patient...
Med Sci Monit In Press; DOI: 10.12659/MSM.942916
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292