27 August 2003
Effects of the addition of a low dose of spironolactone on brain natriuretic peptide plasma level and cardiopulmonary function in patients with moderate congestive heart failure
Mauro Feola, Endrj Menardi, Flavio Ribichini, Antonello Vado, Antonella Deorsola, Valeria Ferrero, Gianluca Visconti, Ugo Milanese, Eugenio UslenghiMed Sci Monit 2003; 9(8): CR341-345 :: ID: 13094
Abstract
Background:The purpose of our study was to assess the effects of a low dose of spironolactone in patients with moderate congestive heart failure (CHF) on the plasma level of brain natriuretic peptide (BNP), echocardiographic left ventricular ejection fraction (LVEF), and cardiopulmonary function assessed by cardiopulmonary (CP) test.Material/Methods:51 CHF patients (74.5% males, mean age 60 years) underwent transthoracic echocardiography, CP test, and plasma BNP assay at the time of enrollment and after 6 months of standard therapy for CHF plus a low dose of spironolactone (group A). A control group (21 patients, group B) was treated using standard therapy only. All subjects were in NYHA class I-III and had LVEF L40%.Results:BNP concentration decreased significantly (from 45.7±57.4 pg/ml to 18.6±26.9 pg/ml at follow-up; p=0.01), and the NYHA class and LVEF improved (2.2±0.6 vs 1.7±0.5, p=0.0001; 27.7±7.2% vs 35.1±11%, p=0.001 respectively) in subjects in group A. In spite of clinical amelioration, peak oxygen consumption, oxygen pulse and anaerobic threshold in the CP test did not change significantly (16.6±5.7 ml/kg/min vs 17.1±5.3 ml/kg/min p=0.5; 8.8I4.3 ml/beat vs 9.5±3.6 ml/beat p=0.2; 0.75±0.2 ml/Kg/min vs 0.73±0.2 ml/Kg/min p=0.7). No differences were noticed in the control group.Conclusions:The addition of spironolactone reduced the BNP plasma level in patients with moderate CHF and increased LVEF. This therapy improved the NYHA class without modifying the functional parameters in the CP test.
Keywords: Aldosterone Antagonists - therapeutic use, Antihypertensive Agents - therapeutic use, Cardiotonic Agents - therapeutic use, Diuretics - therapeutic use, Echocardiography, Heart Failure, Congestive - blood, Heart Failure, Congestive - drug therapy, Natriuretic Peptide, Brain - blood, Spironolactone - therapeutic use, Ventricular Function, Left - physiology
776 14
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
08 Dec 2023 : Clinical Research
Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...Med Sci Monit In Press; DOI:
04 Dec 2023 : Animal Research
Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...Med Sci Monit In Press; DOI:
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292