01 December 2004
Med Sci Monit 2004; 10(12): BR462-467 :: ID: 13226
Background:It is believed that a local recurrence of a primitive breast cancer has the same prognostic factor profile as its primary breast cancer tumor.Material/Methods:We compared the immunohistochemical expressions of the tumor suppressor protein p53, estrogen receptor (ER), c-erbB2, and E-cadherin in 57 primary invasive breast cancers and in their respective LRs. The McNemar test and the kappa index were used for statistical analysis.Results:In 30 patients (52.6%) the expression of at least one of these markers was different between the primary and locally recurrent tumors. No significant difference was observed between variations in the positive and negative expressions in the primary tumor and local recurrence in cerbB2 (kappa=0.86), E-cadherin (kappa=0.55), and p53 (kappa=0.7). However, the ER presented a low kappa index (kappa=0.26, p>0.05).Conclusions:ER expression should be reviewed in local recurrent breast cancer. This relevant change in ER expression is likely to change the current clinical practice in breast cancer evaluation and treatment.
Keywords: Cadherins - analysis, Aged, 80 and over, Breast Neoplasms - pathology, Cadherins - analysis, Neoplasm Recurrence, Local - diagnosis, Prognosis, Receptor, erbB-2 - analysis, Receptors, Estrogen - analysis, Tumor Markers, Biological - analysis, Tumor Suppressor Protein p53 - analysis
01 November 2023 : EditorialEditorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared
Med Sci Monit 2023; 29:e942960
28 Nov 2023 : Clinical ResearchImpact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...
Med Sci Monit In Press; DOI: 10.12659/MSM.942122
28 Nov 2023 : Clinical ResearchLong-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...
Med Sci Monit In Press; DOI: 10.12659/MSM.943031
27 Nov 2023 : Clinical ResearchComparison of Outcomes from Emergency Admissions to a Major Trauma Center in Turkey of 1646 Elderly Patient...
Med Sci Monit In Press; DOI: 10.12659/MSM.942916
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292