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02 October 2003

Host and risk factors for gestational trophoblastic disease: a hospital-based analysis from India

Neeta Kumar, Yogesh Kumar Saxena, Arun Kumar Rathi, Raghunandan Chitra, Pratik Kumar

Med Sci Monit 2003; 9(10): CR442-447 :: ID: 13256

Abstract

Background:Gestational trophoblastic disease (GTD) adversely affects pregnancy by the development of Hydatidiform mole and placental site gestational tumor. GTD is a discrete pool of epidemiological and clinicopathological entities. Therefore, every geographical region should be studied separately. The Indian subcontinent is under-reported for this disease. This paper analyses the data from a large hospital.Material/Methods:92 patients with GTD were analyzed in the period from 1995 to 1999.Results:The incidence of GTD was 1.31 per 1000 live births and one per 967 pregnancies irrespective of outcome. 93.5% of the patients had moderate to severe vaginal bleeding as presenting symptom, while routine antenatal ultrasonography revealed GTD in 6.5% completely asymptomatic patients. Among the major risk factors were age over 30 (p=6.3 x 10[sup]–3[/sup], RR=2.7), previous abortion (p

Keywords: Adolescent, Chorionic Gonadotropin - metabolism, Gestational Trophoblastic Neoplasms - diagnosis, Gestational Trophoblastic Neoplasms - pathology, Hospitals, Hydatidiform Mole - diagnosis, Hydatidiform Mole - pathology, India, Pregnancy, Risk, Risk Factors, Ultrasonography

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750