02 December 2003
The existence of an NAD-dependent pathway for retinoic acid formation from vitamin A (retinol) in rat esophagus and its inhibition by ethanoland histamine 2 (H2) receptor antagonistsHaruko Shiraishi-Yokoyama, Hirokazu Yokoyama, Michinaga Matsumoto, Hiromasa Ishii
Med Sci Monit 2003; 9(12): BR403-406 :: ID: 13415
Background:Retinoic acid is essential for normal cell differentiation and proliferation and disturbance of its metabolism has been implicated in the pathogenesis of various disorders including malignancy. Retinoic acid has been demonstrated to be produced from retinol via a two step oxidation pathway in which alcohol dehydrogenase isozymes have roles. The aim of this study was to know whether the rat esophagus would have the pathway and whether the retinoic acid formation could be disturbed when alcohol dehydrogenase was hampered.Material/Methods:Rat esophageal cytosolic fraction, nicotinamide adenine dinucleotide, and all-trans retinol were incubated together and produced all-trans retinoic acid was detected by high performance liquid chromatography method.Results:Remarkable all-trans retinoic acid formation was observed only when nicotinamide adenine dinucleotide was in existence. The all-trans retinoic acid formation was hampered by addition of ethanol, another substrate of alcohol dehydrogenase, and some histamine 2 receptor antagonists, inhibitors of alcohol dehydrogenase.Conclusions:These results suggest that rat esophagus has an nicotinamide adenine dinucleotide-dependent all-trans retinoic acid formation pathway in which alcohol dehydrogenase is involved. We hypothesize that disturbance of the all-trans retinoic acid formation pathway by ethanol and histamine 2 receptors may cause various esophageal disorders including esophageal cancer seen in alcoholics and subjects taking histamine 2 receptors excessively.
Keywords: Alcohol Dehydrogenase - antagonists & inhibitors, Esophageal Neoplasms - etiology
01 May 2023 : EditorialEditorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy
Med Sci Monit 2023; 29:e940911
31 May 2023 : Review articlePrevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.939919
30 May 2023 : Clinical ResearchA Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...
Med Sci Monit In Press; DOI: 10.12659/MSM.940409
30 May 2023 : Review articleA Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...
Med Sci Monit In Press; DOI: 10.12659/MSM.940550
30 May 2023 : Database AnalysisThe COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940904
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952