Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 December 2003

Age related natural antiviral non-specific immunity of human leukocytes

Katarzyna Rybka, Beata Orzechowska, Iwona Siemieniec, Jerzy Leszek, Ewa Zaczyńska, Jarosław Pająk, Zofia Błach-Olszewska

Med Sci Monit 2003; 9(12): BR413-417 :: ID: 13420

Abstract

Background:The purpose of our study was to examine the dependence of innate antiviral immunity on age and sex in human leukocytes.Material/Methods:Innate antiviral immunity was measured by using the direct method of infection of leukocytes with vesicular stomatitis virus (VSV), which was selected as the indicatory virus for detection of immunity. The lack of VSV replication by infected leukocytes (0–1 log TCID50) was taken as an indicator for complete immunity; a low level of VSV replication (2–3 log) for partial immunity; and a high VSV titer (4 or more log) for the no or very low immunity.Results:The kinetics of VSV replication was studied in leukocytes isolated from 127 individuals ranging in a age from 0 to 89 years. Individual differentiation in the kinetics of VSV replication indicated differing degrees of innate immunity even in newborns. Age-related differences in natural immunity were observed: low immunity in newborns, highest in the age group 31–40, and reduced in the age group >60. Sex dependent innate immunity was shown in the group of aged persons, as innate immunity was higher in women than in men.Conclusions:Innate immunity of leukocytes develops to age 30–40, after which immunity is gradually reduced. Sex dependence was observed only in the group of elderly persons, where women expressed higher immunity; this is probably a reason for their statistically greater longevity.

Keywords: Aged, 80 and over, Aging - immunology, Fetal Blood - cytology, Fetal Blood - immunology, Immunity, Natural, Infant, Newborn, Leukocytes - immunology, Pregnancy, Sex Characteristics, Vesicular stomatitis-Indiana virus - immunology

0 Comments

Editorial

04 June 2022 : Editorial  

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371

SARS-CoV-2/COVID-19

27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

28 Jun 2022 : Meta-Analysis  

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937166  

28 Jun 2022 : Clinical Research  

Serum Calprotectin – a NET Product – as a Biomarker of Disease Activity in Patients with Systemic Lupus Ery...

Med Sci Monit In Press; DOI: 10.12659/MSM.936534  

28 Jun 2022 : Database Analysis  

LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.935070  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750