02 December 2003
Anticardiolipin antibody of adolescents and age of myocardial infarction in parentsRoya Kelishadi, Babak Sabet, Alireza Khosravi
Med Sci Monit 2003; 9(12): CR515-518 :: ID: 13424
Background:The objective of our research was to study anticardiolipin antibody (ACLA) in the offspring of families at high risk for premature coronary heart disease (CHD) in comparison to controls, and the degree of agreement between ACLA levels in parents and children.Material/Methods:In an analytical case-control study, three paired parent-child groups of 50 each were selected by simple random sampling, and their IgG ACLA levels measured by ELISA method. A comparison was made between parents who had premature myocardial infarction (MI55 years and one child, and parents with no history of heart attacks and one child as the first and second control groups, respectively.Results:The prevalence of positive ACLA in adolescents in the case group was significantly higher than the second control group (P=0.03), but this difference was not significant against the first control group (p>0.05). Regarding parents, there were significant differences between the case group and both control groups (P=0.04 and P=0.009, respectively). A substantial degree of correlation was found between positive ACLA in patients with premature MI and their children (kappa correlation coefficient =0.63, 95% CI, 0.47–0.79).Conclusions:The findings of this study point to the probable presence of a familial immunological background in the onset of premature atherosclerosis with regard to ACLA, which can be measured as a risk factor in predicting premature CHD.
Keywords: Adolescent, Antibodies, Anticardiolipin - blood, Case-Control Studies, Child, Myocardial Infarction - genetics, Myocardial Infarction - immunology, Parents, Risk Factors
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
01 Jun 2023 : Clinical ResearchRoot Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical ResearchInternal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease
Med Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical ResearchEffectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...
Med Sci Monit In Press; DOI: 10.12659/MSM.940187
01 Jun 2023 : Clinical ResearchInfluence of Insulin Resistance on Diabetes Nephropathy
Med Sci Monit In Press; DOI: 10.12659/MSM.939482
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952