Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

25 October 2004

Induction of pro-inflammatory cytokine gene expression and apoptosis in human chorion cells of fetal membranes by influenza virus infection: possible implications for maintenance and interruption of pregnancy during infection

Noboru Uchide, Kunio Ohyama, Toshio Bessho, Hiroo Toyoda

Med Sci Monit 2005; 11(1): RA7-16 :: ID: 13886

Abstract

Human fetal membranes are composed of amnion, chorion and decidua tissues, which play a critical role in defense barriers as well as maintenance of pregnancy and parturition. Pro-infl ammatory cytokines, such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α, produced by the tissues are postulated to facilitate parturition. Infl uenza virus infection is one of causes of pregnancy-
associated complications, such as premature delivery, abortion and stillbirth. Recent studies have demonstrated that infl uenza virus infection induced the gene expression of a set of pro-infl ammatory
cytokines, such as IL-1β, IL-6, TNF-α, interferon (IFN)-β, IFN-g and granulocyte macrophage colony-stimulating factor (GM-CSF), and the secretion of unidentifi ed monocyte differentiationinducing factor(s) from primary cultured chorion cells undergoing apoptosis. These phenomena were not observed in primary cultured amnion cells infected with the virus. This article reviews,1) the production of cytokines in fetal membrane tissues and their functions; 2) the differential induction of pro-infl ammatory cytokine gene expression and apoptosis in fetal membrane chorion and amnion cells by infl uenza virus infection. An accumulating number of evidence suggests that interactive reactions between fetal membrane chorion cells and maternal monocytes/macrophages may play a critical role in defense barriers against the virus infection. Understanding the interactions would make important contributions to the elucidation of the pathogenesis of infl uenza virus infection during pregnancy.

Keywords: Amnion - immunology, Amnion - virology, Chorion - immunology, Chorion - virology, Decidua - virology, Extraembryonic Membranes - immunology, Extraembryonic Membranes - virology, Influenza, Human - complications, Influenza, Human - immunology, Pregnancy Complications, Infectious - metabolism, Amnion - virology, Chorion - virology, Cytokines - genetics, Decidua - virology, Extraembryonic Membranes - virology, Influenza, Human - immunology, Pregnancy, Pregnancy Complications, Infectious - metabolism

Add Comment 0 Comments

Editorial

01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911

0:00

In Press

05 Jan 2024 : Clinical Research  

Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurger...

Med Sci Monit In Press; DOI: 10.12659/MSM.942585  

02 Jan 2024 : Clinical Research  

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Med Sci Monit In Press; DOI: 10.12659/MSM.942819  

29 Dec 2023 : Clinical Research  

Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Prima...

Med Sci Monit In Press; DOI: 10.12659/MSM.942747  

08 Jan 2024 : Review article  

Review of Approaches to the Management of Vertical Dental Root Fractures and Tooth Preservation

Med Sci Monit In Press; DOI: 10.12659/MSM.943100  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750