Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 February 2005

Genes arrayed out for you: the amazing world of microarrays

Joydeep D. Chaudhuri

Med Sci Monit 2005; 11(2): RA52-62 :: ID: 14231


Microarrays, a recent development, have provided a revolutionary platform for the study of gene expression, regulation and function. Thus, it has tremendous potential in the study of biological processes in health and disease. Notable examples include the identification of regulatory genes in the cell cycle mechanism, and disease causing genes in malignancies and certain neurodegenerative disorders. Therefore, microarray-based studies have provided the necessary impetus for biomedical experiments, particularly following the sequencing of the human genome. However, it must be emphasized that microarrays are not the sole purview of biologists, but represent the amalgamation of the efforts of biomedical scientists, technologists and statisticians. This is particularly considering the challenges in the manufacture of microarrays and supporting equipment, and the meaningful analyses of the tremendous volume of data generated by these experiments. In this article, the principles and technological concerns regarding microarrays and microarray-based experiments, the steps involved in obtaining and the rationale of analyses of data derived from these experiments is reviewed. Further, some aspects of microarray-based experimentation, such as experimental design, and data handling and interpretation are discussed. However, as with all novel methods there is still scope for improvement. The relative merits and demerits of microarrays and analysis of microarray based data are reviewed, along with current issues of concern and future possibilities. Thus, the overall aim of this article is to highlight some of the past and potential future uses of microarray-based experiments and present a broad overview of this rapidly growing technology.

Keywords: Gene Expression Profiling - instrumentation, Oligonucleotide Array Sequence Analysis - classification, Oligonucleotide Array Sequence Analysis - instrumentation, Oligonucleotide Array Sequence Analysis - trends, Gene Expression Profiling - trends, Oligonucleotide Array Sequence Analysis - trends, Reproducibility of Results, Terminology as Topic



01 July 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937676

Med Sci Monit 2022; 28:e937676


27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

05 Jul 2022 : Clinical Research  

Attention-Deficit/Hyperactivity Disorder (ADHD) and Time Perception in Adults: Do Adults with Different ADH...

Med Sci Monit In Press; DOI: 10.12659/MSM.936849  

01 Jul 2022 : Clinical Research  

Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?

Med Sci Monit In Press; DOI: 10.12659/MSM.936792  

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750