02 May 2003
The effects of etoposide and niacin deficiency on bone marrow NAD+ and telomere length in Long-Evans rats
A. Bartleman, J KirklandMed Sci Monit 2003; 9(1): 2-0 :: ID: 14987
Abstract
Weanling male Long-Evans rats were fed niacin deficient (ND) or niacin replete (pair-fed control, PF) (30 mg nicotinic acid/kg) diet for 3 weeks. After 2 weeks of feeding, pairs of ND and PF rats were randomly assigned to receive oral etoposide (40mg/kg body weight) (ETO) or soy oil vehicle (V) for 7 consecutive days while remaining on their ND or PF diet. Three hours following the last dose of etoposide or vehicle, rats were euthanised and bone marrow and blood collected. Niacin deficiency alone caused an 80% decrease in bone marrow NAD+ relative to PF rats: surprisingly, ETO treatment of ND rats caused a 3.0 fold increase in the NAD+ status of the bone marrow. In PF-ETO rats there was also an NAD+ response, with a 1.25 fold increase over PF-V rats. Blood NAD+ did not differ between PF-V and PF-ETO rats, but was increased 1.5 fold in ND-ETO vs. ND-V. Telomere length in ND-V rats was found to be decreased by 10% relative to PF-V rats (p
Keywords: niacin, Telomere, Etoposide, NAD+
Editorial
01 October 2024 : Editorial
Editorial: Potentials and Pitfalls in Targeting Glucagon-Like Peptide-1 (GLP-1) in the Management of Increasing Levels of ObesityDOI: 10.12659/MSM.946675
Med Sci Monit 2024; 30:e946675
In Press
Clinical Research
Minimally Invasive Combined Medial and Lateral Approach for Treating Displaced Scapular Body and Neck Fract...Med Sci Monit In Press; DOI: 10.12659/MSM.945535
Clinical Research
Evaluation of Neuromuscular Blockade: A Comparative Study of TOF-Cuff® on the Lower Leg and TOF-Scan® on th...Med Sci Monit In Press; DOI: 10.12659/MSM.945227
Clinical Research
Acupuncture Enhances Quality of Life and Disease Control in Chronic Spontaneous Urticaria Patients on Omali...Med Sci Monit In Press; DOI:
Review article
Sex and Population Variations in Nasopalatine Canal Dimensions: A CBCT-Based Systematic ReviewMed Sci Monit In Press; DOI:
Most Viewed Current Articles
17 Jan 2024 : Review article 6,057,160
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,850,676
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 693,861
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 258,144
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074