Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 May 2003

The effects of etoposide and niacin deficiency on bone marrow NAD+ and telomere length in Long-Evans rats

A. Bartleman, J Kirkland

Med Sci Monit 2003; 9(1): 2-0 :: ID: 14987


Weanling male Long-Evans rats were fed niacin deficient (ND) or niacin replete (pair-fed control, PF) (30 mg nicotinic acid/kg) diet for 3 weeks. After 2 weeks of feeding, pairs of ND and PF rats were randomly assigned to receive oral etoposide (40mg/kg body weight) (ETO) or soy oil vehicle (V) for 7 consecutive days while remaining on their ND or PF diet. Three hours following the last dose of etoposide or vehicle, rats were euthanised and bone marrow and blood collected. Niacin deficiency alone caused an 80% decrease in bone marrow NAD+ relative to PF rats: surprisingly, ETO treatment of ND rats caused a 3.0 fold increase in the NAD+ status of the bone marrow. In PF-ETO rats there was also an NAD+ response, with a 1.25 fold increase over PF-V rats. Blood NAD+ did not differ between PF-V and PF-ETO rats, but was increased 1.5 fold in ND-ETO vs. ND-V. Telomere length in ND-V rats was found to be decreased by 10% relative to PF-V rats (p

Keywords: niacin, Telomere, Etoposide, NAD+

Add Comment 0 Comments

225 0


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209


In Press

01 Jun 2023 : Clinical Research  

Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940472  

01 Jun 2023 : Clinical Research  

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Med Sci Monit In Press; DOI: 10.12659/MSM.940873  

01 Jun 2023 : Clinical Research  

Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...

Med Sci Monit In Press; DOI: 10.12659/MSM.940187  

01 Jun 2023 : Clinical Research  

Influence of Insulin Resistance on Diabetes Nephropathy

Med Sci Monit In Press; DOI: 10.12659/MSM.939482  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750