Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 May 2003 : Case report  

Topical treatment with BGP-15M, a poly(ADP-ribose) polymerase inhibitor protects from ultraviolet radiation-induced skin cancer in vivo

B. Farkas, M. Magyarlaki, B. Csete, S. Bernath

Med Sci Monit 2003; 9(1): 25- :: ID: 15075

Abstract

Experimental data suggest that enzymes and substances, which decrease DNA-damage or improve repair can be used as photoprotective agents. These observations have led to the development of new strategies to facilitate DNA-repair in human cells and thereby improve photoprotection [1–3]. UV-irradiation may have deleterious effects on the DNA of skin cells. Indeed, UV-irradiation is capable of inducing extensive DNA-damage that overactivates PARP causing increased energy demand, which in turn may result in collapse of energy metabolism and in cell death. This suggests that moderation of PARP activity following DNA-damage may protect skin cells from the harmful effects of acute and chronic UV-exposure.The effects of BGP-15M, a topically applied novel PARP-inhibitor on UV-induced acute and chronic photodamage were investigated in a hairless mouse model and in human skin. DNA injury was detected by measuring the formation of single-strand DNA breaks and counting sunburn cells. The ADP-ribosylation of PARP was assessed by Western blot analysis. Immunosuppression was investigated in epidermal cells by detecting TNFá and IL-10 expression. UV-induced photocarcinogenesis was determined by clinical, immunohistochemical, and biochemical methods. It has been observed that BGP-15M protects against the clinical and histopathological signs of long-term (26 week) UVA exposure in 8-methoxipsoralen sensitized skin, and decreases the UVB-induced accumulation of mutations and deletions in tumor suppressor genes. Topical treatment with BGP-15M prevents photocarcinogenesis induced by long-term, 32 week-UVB or 26 week-UVA exposure in hairless mice. The above observations carry the promise of a novel type biological skin protective agent against UV-induced photocarcinogenesis, which can revolutionize sun protection in the coming years. References: 1.Yarosh D et al: Lancet, 2001; 357: 926 2.Farkas B et al: Biochem Pharmacol, 2002; 63: 921 3.Farkas B et al: Pharmacology & Toxicology Series, Boca Raton, London, Washington, CRC Press 2002; pp: 257

Keywords: topical PARP-inhibitor, skin cancer, UVA, UVB, photoprotection

Add Comment 0 Comments

283 0

Editorial

01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

0:00

In Press

31 May 2023 : Review article  

Prevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939919  

30 May 2023 : Clinical Research  

A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...

Med Sci Monit In Press; DOI: 10.12659/MSM.940409  

30 May 2023 : Review article  

A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...

Med Sci Monit In Press; DOI: 10.12659/MSM.940550  

30 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750