02 May 2003
Inhibition of poly(ADP-ribose)polymerase (PARP) by INO-1001 attenuates ovine acute lung injury in an ovine model of sepsis following smoke inhalation injury
K. Murakami, P. Enkhbaatar, K. Shimoda, R. Cox, H. Hawkins, F. Schmalstieg, L. Traber, A. Salzman, J. Mabley, K. Komjati, P. Pacher, Z. Zsengeller, C. Szabo, D. TraberMed Sci Monit 2003; 9(1): 47- :: ID: 15110
Abstract
Background:Activation of PARP results in a significant decrease in intracellular NAD+ and ATP, which are major intracellular energy stores. We hypothesized that the inhibition of PARP would improve the ovine model of acute lung injury following smoke inhalation and pneumonia. Material/Methods:Female sheep (n=10) were used. After the 48 breaths of cotton smoke (
Keywords: Sheep, Histology, pseudomonas pneumonia
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