Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2003 : Review article  

Chronic hepatitis C among patients from Department of Infectious Diseases in Gdańsk –epidemiology and some clinical aspects

K. Sikorska, E. Lakomy, Z. Michalska, P. Stalke, K. Witczak-Malinowska

Med Sci Monit 2003; 9(2): 15- :: ID: 15272


Background:The aim of the study was to perform epidemiological and clinical evaluation among patients with diagnosis of chronic hepatitis C,that were admitted to Department of Infectious Diseases to qualify to antiviral treatment in 1999-2002 yrs.Material/Methods:Retrospective analysis of 255 cases with collection of demographical and epidemiological data was made. We analysed inflammatory activity and fibrosis stage in histopathological examination of the liver specimen and frequency of extrahepatic manifestation of HCV infection.Results:There were 165 men and 89 women,from 18 to 68 yrs,the most often in age of 30 –50yrs.Inoculation was confirmed among 130 patients (51%),27 were health care workers (10.6%).HCV infection among patients without typical symptoms of hepatitis was suspected in 31 cases (12.2%)on routine examinations at place of work or on screening at Blood Donation Centre.Among 34 patients (13.3%)abnormal liver function tests were detected during diagnosis or treatment because of other diseases.The most often interval from probable inoculation to the moment of ascertainment of chronic hepatitis C was 10 –20 yrs.22 (8.6%)patients with chronic hepatitis C were treated previously because of acute hepatitis C.The average time that passed from appearance of first symptoms to determine indications to antiviral treatment in the whole group was contained between 5-10yrs. Histopathological evaluation of liver revealed mostly moderate grade of fibrosis and necroinflammatory process.Cirrhosis was diagnosed in 14 cases (5.5%).Extrahepatic manifestation of HCV infection was diagnosed in 29/255 cases (11.4%)(4 cases of porphyria cutanea tarda,1 case of neurodermitis,1 case of Duhring disease and 23 cases of cryoglobulinemia with symptoms of vasculitis /8/,reactive arthritis /8/and thrombocyto- penia /7/). Conclusions: 1.Clinical course of chronic hepatitis C is often occult and symptomless with slow progression to cirrhosis in some cases 2. Accurate diagnosis of this disease is established after many years from the moment of probable inoculation in great number of cases.3.Qualification to antiviral treatment sometimes is delayed because of nonspecific symptoms or late proper diagnosis.4.HCV infection relatively often takes a course with extrahepatic manifestation.




01 July 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937676

Med Sci Monit 2022; 28:e937676


27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

05 Jul 2022 : Clinical Research  

Attention-Deficit/Hyperactivity Disorder (ADHD) and Time Perception in Adults: Do Adults with Different ADH...

Med Sci Monit In Press; DOI: 10.12659/MSM.936849  

01 Jul 2022 : Clinical Research  

Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?

Med Sci Monit In Press; DOI: 10.12659/MSM.936792  

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750