Background:The infection of Helicobacter pylori (H.pylori)in Polish population is assessed at 73 –87%.The aim was the investigation of the relation between chronic liver disease and the frequency of H.pylori infection in gastric mucosa.Material/Methods:111 patients (49 females,62 men),aged 18 –67 (mean 40 years)were admitted to the hospital because of liver diseases.In all cases liver oligobiopsy, gastroscopy with CLO test and IgG anti-H.pylori were conducted.The gastroscopy was performed because of symptoms of dyspepsia or suspicions of portal hypertension.Results:The infections:HCV in 53/111 and HBV in 17/111 cases were found.In other 30 out of 11 cases,the toxic liver damage in 14/111,autoimmune diseases in 14/111, hemochromatosis in 1/111,Wilson ’s disease in 2/111 and multifactorial liver diseases in 10/111 cases were diagnosed.In 98/111 (88%) the signs of gastric mucosa inflammation were found. The infection of H.pylori in gastric mucosa was confirmed by rapid urease test (CLO-test) in 101/111 (91%)cases.In patients without gastric inflammation in gastroscopy CLO-test was positive in 10/13 cases.Serodiagnosis for H.pylori infection was positive in 70 cases out of 101 patients tested (69%).We found a relation between results of gastroscopy and CLO-test (p=0.0054,Tau=0.18),but not with serology of H.pylori. There was no relation between aetiology of liver diseases and the frequency of H.pylori infection.Conclusions:The H.pylori infection in patients with chronic liver diseases seems to occur more often than in the general population.The CLO-test is superior to serological tests.