01 April 2005
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm
Marek Gacko, Roman Ostapowicz, Lech Chrostek, Anna Worowska, Kazimierz KordeckiMed Sci Monit 2005; 11(4): CR211-213 :: ID: 15889
Abstract
Background:The wall of an abdominal aorta aneurysm shows increased activity of metalloproteinases, aspartyl cathepsins and cystein cathepsins, and decreased activity of inhibitors of these enzymes, as compared to the wall of a normal aorta. Parietal thrombi of the aneurysm also show marked proteolytic activity. The aim of our study was to determine the activity of secretory enzymes, membrane enzymes, cytosol enzymes, mitochondrial enzymes and lysosomal enzymes in the blood plasma of patients with abdominal aortic aneurysm.Material/Methods:Blood for examinations was collected from 15 patients with abdominal aorta aneurysm without coexisting diseases, and from the same number of healthy subjects, to determine the activity of lactic acid dehydrogenase (LDH), 5’ nucleotidase (5’NT), gamma-glutamyltranspeptidase (GGTP) and cholinesterase (ChE), alanine aminotransferase (ALT), aspartic aminotransferase (AST), cathepsin B (CB), cathepsin D (CD), and cathepsin L (CL).Results:The plasma activity of ALT, AST and GGTP in the blood of patients with aortic aneurysm is lower than in the plasma of healthy subjects. The activity of LDH, 5’NT and ChE, CB and CL does not significantly differ in the plasma of patients with aortic aneurym compared to the plasma of healthy subjects. The activity of CD is increased in the plasma of patients with aortic aneurysm.Conclusions:Determination of cathepsin D activity may be helpful in the diagnosis of aortic aneurysm.
Keywords: Alanine Transaminase - blood, Aortic Aneurysm - blood, Aortic Aneurysm - enzymology, Aspartate Aminotransferases - blood, Cathepsins - blood, Enzymes - blood, Lymphocytes - enzymology, Metalloproteases - blood, Subcellular Fractions - enzymology, Alanine Transaminase - blood, Aortic Aneurysm - enzymology, Aspartate Aminotransferases - blood, Cathepsins - blood, Enzyme Inhibitors - blood, Enzymes - blood, Lymphocytes - enzymology, Metalloproteases - blood, Neutrophils - enzymology, Reference Values, Subcellular Fractions - enzymology, gamma-Glutamyltransferase - blood
Editorial
01 February 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadDOI: 10.12659/MSM.939580
Med Sci Monit 2023; 29:e939580
SARS-CoV-2/COVID-19
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
06 Feb 2023 : Clinical Research
Double C-Arm Digital Subtraction Angiography Guidance During Transjugular Intrahepatic Portosystemic Shunt ...Med Sci Monit In Press; DOI: 10.12659/MSM.938912
06 Feb 2023 : Review article
Evolution of Hybrid Intelligence and Its Application in Evidence-Based Medicine: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.939366
03 Feb 2023 : Clinical Research
Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...Med Sci Monit In Press; DOI: 10.12659/MSM.938865
02 Feb 2023 : Clinical Research
Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...Med Sci Monit In Press; DOI: 10.12659/MSM.938672
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952