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01 April 2005 : Original article  

Randomized, controlled study of the effects of losartan versus enalapril in small doses on proteinuria and tubular injury in primary glomerulonephritis

Leszek Tylicki, Marcin Renke, Przemysław Rutkowski, Bolesław Rutkowski, Wiesława Łysiak-Szydłowska

Med Sci Monit 2005; 11(4): PI31-37 :: ID: 15897

Abstract

Background:Pharmacological blockade of the renin-angiotensin-aldosteron system ameliorates glomerular and tubulointerstitial damage. For optimal renoprotection, high doses of angiotensin II converting enzyme inhibitors and angiotensin II subtype 1 receptor antagonists are commonly recommended, but cannot always be administered. The aim of this study was to evaluate the effects of low-dose (25 mg) losartan on proteinuria and tubular injury extent.Material/Methods:This was an open, randomized, 12-month study on the effects of 25 mg of losartan (n=19) vs. 10 mg of enalapril (n=14) as a control on proteinuria, urinary excretion of N-acetyl- β -D-glucosaminidase (NAG), and blood pressure in patients with primary glomerulonephritis. The second part of the study was an uncontrolled assessment of the renal effects of 50-mg administration of losartan.Results:There were no significant differences between the groups in the effects on proteinuria and NAG excretion. Losartan and enalapril reduced proteinuria by 32.8% (p

Keywords: Anti-Arrhythmia Agents - therapeutic use, Angiotensin-Converting Enzyme Inhibitors - therapeutic use, Angiotensin II Type 1 Receptor Blockers - therapeutic use, Blood Pressure, Creatinine - blood, enalapril, Glomerulonephritis - drug therapy, Kidney Tubules - pathology, Losartan - therapeutic use, Proteinuria - prevention & control

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750