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01 June 2005 : Original article  

Mitochondrial changes induced by trimetazidine in the myocardium

Pedro J. Morillas Blasco, Amparo Hernándiz Martinez, Immaculada Azorín Villena, Manuel Portolés Sanz, Vicente Pallarés Carratalá, Vicente Bertomeu Martínez, Carmen Capdevilla Carbonell, Amparo Aguilar Llopis, Juan Cosín Aguilar

Med Sci Monit 2005; 11(6): BR162-167 :: ID: 16479

Abstract

Summary
Background: The aim was to assess the effect of trimetazidine (TMZ) on mitochondrial alterations induced in a canine model of brief, repeated episodes of ischemia.
Material/Methods: Twelve crossbred dogs were analyzed, after double-blind randomization, to a 7-day treatment with either TMZ or placebo. Twenty brief, complete occlusions of the left anterior descending coronary artery were performed. Mitochondrial analysis entailed a qualitative (percentage of mitochondrial damage, merging, pairing, vacuoles, and lipofucsin granules) and a quantitative size analysis (major and minor axes, perimeter, and area) of the mitochondria in the ischemic and control zones.
Results: Comparative study of the control zones revealed an increase in lipofucsin granules in the TMZ series and a greater percentage of damaged mitochondria and vacuoles. The control-zone mitochondria
treated with TMZ presented a signifi cant increase in the perimeter and major axis and a decrease in the minor axis (p

Keywords: Lipofuscin - metabolism, Mitochondria, Heart - pathology, Mitochondria, Heart - ultrastructure, Myocardial Ischemia - chemically induced, Trimetazidine - pharmacology, Dogs, Double-Blind Method, Heart - physiology, Lipofuscin - metabolism, Mitochondria, Heart - ultrastructure, Models, Animal, Myocardial Ischemia - pathology, Random Allocation, Trimetazidine - pharmacology, Vasodilator Agents - pharmacology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750