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01 June 2005 : Original article  

Evaluation of lipid peroxidation, oxidant/antioxidant status, and serum nitric oxide levels in alopecia areata

Rafet Koca, Ferah Armutcu, H. Cevdet Altinyazar, Ahmet Gürel

Med Sci Monit 2005; 11(6): CR296-299 :: ID: 16507


Background: The pathophysiology of alopecia areata (AA) has not been clearly defi ned; however, it appears as a tissue-restricted autoimmune disease mediated by T lymphocytes. Immunohistochemical studies have shown peri- and infra-follicular infl ammatory infi ltrate which damages hair follicles. We analyzed
the role of lipid peroxidation and oxidant-antioxidant enzymes in the pathogenesis of AA.
Material/Methods: Twenty-four patients with AA and 20 age- and sex-matched healthy controls were enrolled in this study. We analyzed serum levels of malondialdehyde (MDA) and nitric oxide (NO) and the serum activities of superoxide dismutase (SOD) and xanthine oxidase (XO) in patients with AA and control subjects.
Results: The levels of MDA and NO (nitrite/nitrate) and the activity of XO in serum of patients with AA (0.76±0.34 nmol/ml, 14.88±6.40 nmol/ml, and 0.34±0.10 U/ml, respectively) were signifi cantly
higher than those of controls (0.35±0.09 nmol/ml, 10.71±1.75 nmol/ml, 0.11±0.03 U/ml; p

Keywords: Alopecia Areata - blood, Xanthine Oxidase - blood, Adolescent, Alopecia Areata - blood, Antioxidants - metabolism, Biological Markers - blood, Lipid Peroxidation, Malondialdehyde - blood, Nitric Oxide - blood, Oxidants - metabolism, Reference Values, Superoxide Dismutase - blood, Xanthine Oxidase - blood



04 June 2022 : Editorial  

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371


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Med Sci Monit In Press; DOI: 10.12659/MSM.936534  

28 Jun 2022 : Database Analysis  

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Med Sci Monit In Press; DOI: 10.12659/MSM.935070  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750