Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 2005 : Extended abstract from EFAS 2011  

Liquid-liquid systems for acid hydrolysis of glycoalkaloids from Solanum tuberosumL. tuber sprouts and solanidine extraction.

Nada C Nikolic, Mihajlo Z Stankovic, Dejan Z Markovic

Med Sci Monit 2005; 11(7): BR200-205 :: ID: 16971

Abstract

Background: Potato sprouts(Solanum tuberosum L.) contain steroidal glycoalkaloidscontaining solanidine, an important precursor for hormone synthesis. Glycoalkaloids are reported to inactivatethe Herpes simplex, Herpes zoster and Herpes genitalis viruses in humans, while Aglyones, including solasodine,may protect against skin cancer. Extracts of glycoalkaloids or solanidine can be used to obtain a potentialskin cancer preparation for clinical research. Material/Methods: Dried potato sprouts were used to obtainglycoalkaloids and solanidine. The hydrolysis of glycoalkaloids in a liquid-liquid system was performedusing a reflux condenser, obtaining extracts of glycolakaloids from dried and milled potato tuber sprouts.Hydrochloric acid was then added to the extract to form the first (aqueous) phase, and chloroform, trichloroethyleneor carbon tetrachloride to form the second (organic) phase of the liquid-liquid system. In this way,glycoalkaloid hydrolysis to solanidine and solanidine extraction in the organic liquid phase were combinedinto a single step. IR and GC/MS analysis of solanidine was also conducted. Results: Based on the resultswe obtained, the optimal liquid-liquid system was found to be 2% w/v hydrochloric acid in a 50% (volume)methanolic extract of glycoalkaloids from tuber sprouts, as the first phase, and chloroform as the secondphase. Using this system, a yield of 1.46 g solanidine per 100 g of dried potato sprouts can be achieved.Conclusions: Glycoalkaloid hydrolysis in a liquid-liquid system yields the aglycone solanidine can beobtained from dried potato sprouts. The yield of solanidine is higher than that obtained using solid-liquid-liquidsystems for glycoalkaloid hydrolysis from potato vines.

Keywords: Plant Shoots - chemistry, Solanaceous Alkaloids - chemistry, Solanaceous Alkaloids - isolation & purification, Chloroform, Diosgenin, Hydrochloric Acid, Hydrolysis, Methanol, Plant Extracts - isolation & purification, Plant Shoots - chemistry, Solanaceous Alkaloids - isolation & purification, Solanum tuberosum - chemistry, Solvents

Add Comment 0 Comments

Editorial

01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911

0:00

In Press

08 Feb 2024 : Clinical Research  

Predictors of Mortality in Veterans with Amyotrophic Lateral Sclerosis: Respiratory Status and Speech Disor...

Med Sci Monit In Press; DOI: 10.12659/MSM.943288  

0:00

25 Feb 2024 : Clinical Research  

Patterns and Outcomes of Traumatic Suicides: A Retrospective Study of 132 Patients Admitted to a Turkish Me...

Med Sci Monit In Press; DOI: 10.12659/MSM.943505  

0:00

01 Feb 2024 : Review article  

Review of the Evaluation of Pulmonary Hypoplasia as an Important Determinant of Clinical Outcomes in Infant...

Med Sci Monit In Press; DOI: 10.12659/MSM.943259  

0:00

19 Feb 2024 : Clinical Research  

Diagnostic Accuracy of Ileocolic Artery and Vein Diameter for Acute Appendicitis

Med Sci Monit In Press; DOI: 10.12659/MSM.943846  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750