01 July 2005 : Extended abstract from EFAS 2011
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Hossam M M ArafaMed Sci Monit 2005; 11(7): BR228-234 :: ID: 16975
Abstract
Background: Curcumin (a component of turmeric) has long been used as aspice and food-coloring agent. In experimental animals, curcumin has shown anti-diabetic, anti-inflammatory,cytotoxic and anti-oxidant properties. Material/Methods: The possible hypolipidemic effect of curcuminwas investigated in rats fed a high-cholesterol diet (HCD). The lipid profile and activities of aspartateaminotransferase (AST) and alanine aminotransferase (ALT) were assessed in serum, as well as anti-oxidantparameters in liver tissues. Results: Feeding the animals a high cholesterol diet (HCD) for 7 consecutivedays (1 ml 100 g(-1)) resulted in marked hypercholesterolemia, increased serum level of low-density lipoproteincholesterol (LDL-C), but a decreased serum high-density lipoprotein cholesterol (HDL-C). Curcumin admixedwith the diet (0.5% w/w) decreased serum total cholesterol (TC) by about 21% and LDL-C by 42.5%, butit increased serum HDL by 50%. The atherogenic indices (LDL-C/HDL-C and TC/HDL-C) were reduced by 52%and 35%, respectively. Curcumin also decreased the enzyme activities of serum AST and ALT, which wereincreased in HCD animals. Conclusions: Curcumin showed an obvious hypocholesterolemic effect that couldbe due to an effect on cholesterol absorption, degradation or elimination, but not due to an anti-oxidantmechanism. This could be supported by the finding in our study that neither HCD nor curcumin-admixedHCD had any effects on the liver content of glutathione (GSH) or superoxide dismutase (SOD) activity.Thus one could argue that ingestion of curcumin-containing spices in the diet, especially one rich infats, could have a lipid-lowering effect.
Keywords: Alanine Transaminase - antagonists & inhibitors, Aspartate Aminotransferases - antagonists & inhibitors, Curcumin - therapeutic use, Alanine Transaminase - antagonists & inhibitors, Aspartate Aminotransferases - antagonists & inhibitors, Cholesterol - blood, Cholesterol, Dietary - adverse effects, Cholesterol, HDL - blood, Cholesterol, LDL - blood, Curcumin - therapeutic use, Hypercholesterolemia - etiology, Hypolipidemic Agents - therapeutic use, Liver - enzymology
Editorial
01 November 2024 : Editorial
Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and PrognosisDOI: 10.12659/MSM.947038
Med Sci Monit 2024; 30:e947038
In Press
Clinical Research
Clinical Outcomes of Talus Bone Marrow Edema: Comparing Plaster Cast, Crutches, and Walking Boot TreatmentsMed Sci Monit In Press; DOI: 10.12659/MSM.946072
Review article
Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and PharmacokineticsMed Sci Monit In Press; DOI: 10.12659/MSM.945582
Clinical Research
Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...Med Sci Monit In Press; DOI: 10.12659/MSM.944912
Clinical Research
Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...Med Sci Monit In Press; DOI: 10.12659/MSM.946265
Most Viewed Current Articles
17 Jan 2024 : Review article 6,335,406
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,908,931
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 695,409
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 260,542
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074