01 July 2005 : Extended abstract from EFAS 2011
Possible induction of oral allergy syndrome during specific immunotherapy inpatients sensitive to tree pollen.
Marek Modrzyński, Edward ZawiszaMed Sci Monit 2005; 11(7): CR351-355 :: ID: 16984
Abstract
Background: Many studies have shown that specific immunotherapy may preventthe development of allergies to new allergens. Recently, however, there have been sporadic reports onthe possibility of new allergies developing during immunotherapy. The aim of this study was to evaluatethe possibility of the occurrence of food allergy and changes of sIgE concentration in patients sensitiveto tree pollen during specific immunotherapy Material/Methods: We examined 12 patients subjected to desensitizationtreatment of pollinosis caused by allergy to the pollen of Betulaceae trees, in whom only Bet v 1 sIgEwas found in serum prior to immunotherapy. The control group included 8 allergic patients who did notconsent to this treatment. Results: Bet v 2 sIgE was detected after 6 months in 3 patients (25%) andafter 18 months in another 2 patients (41.7% total). In 2 cases, oral allergy syndrome (OAS) occurredin the course of therapy. These findings were accompanied by a concomitant decrease in nasal and ocularallergic signs during the birch pollen season in the overwhelming majority of patients (91.7%). In thecontrol group, no serum occurrence of Bet v 2 sIgE was found during the 18-month observation period.Although no OAS signs appeared in any patient, the symptomatic intensity of pollinosis was not reduced.Conclusions: Due to the limitations of currently used vaccines, new allergies may be induced during immunotherapy.In sporadic cases these may be accompanied by the occurrence of specific clinical manifestations, usuallymild.
Keywords: Betula - immunology, Desensitization, Immunologic - adverse effects, Food Hypersensitivity - etiology, Food Hypersensitivity - immunology, Hypersensitivity - immunology, Hypersensitivity - therapy, Immunoglobulin E - blood, Pollen - immunology, Syndrome, Betula - immunology, Desensitization, Immunologic - adverse effects, Food Hypersensitivity - immunology, Hypersensitivity - therapy, Immunoglobulin E - blood, Pollen - immunology, Syndrome
579 6
Editorial
01 May 2023 : Editorial
Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor TherapyDOI: 10.12659/MSM.940911
Med Sci Monit 2023; 29:e940911
In Press
31 May 2023 : Review article
Prevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.939919
30 May 2023 : Clinical Research
A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...Med Sci Monit In Press; DOI: 10.12659/MSM.940409
30 May 2023 : Review article
A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...Med Sci Monit In Press; DOI: 10.12659/MSM.940550
30 May 2023 : Database Analysis
The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in PolandMed Sci Monit In Press; DOI: 10.12659/MSM.940904
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952