Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 2005 : Case report  

COX-2 inhibitors and metabolism of essential fatty acids.

Undurti N Das

Med Sci Monit 2005; 11(7): RA233-237 :: ID: 16986


Selective COX-2 inhibitors increase the risk of myocardial infarction andstroke that is attributed to their ability to inhibit prostacyclin (PGI(2)), lipoxins, resolvins, andendothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A(2) (TXA(2)). In contrast,aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations ofdihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoicacid (DHA) and reduced formation of eicosanoids. On the other hand, such an increase is much less withspecific COX-2 inhibitors since they do not block the formation of eicosanoids through COX-1 pathway.DGLA, AA and EPA form precursors to PGE(1) , PGI(2), and PGI(3) respectively, which are potent vasodilatorsand platelet anti-aggregators, and thus aid in the prevention of thrombus formation. EPA has anti-arrhythmicaction, and EPA, DHA (docosahexaenoic acid), DGLA, and PGE(1) have anti-inflammatory actions as well.EPA, DHA, and AA augment eNO formation that has anti-atherosclerotic action. Hence, combining EFAs withCOX-2 inhibitors will prevent thrombotic cardiovascular events.

Keywords: Epoprostenol - antagonists & inhibitors, Epoprostenol - metabolism, Anti-Inflammatory Agents, Non-Steroidal - pharmacology, Aspirin - pharmacology, Cardiovascular Diseases - metabolism, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors - pharmacology, Eicosanoids - biosynthesis, Epoprostenol - metabolism, Fatty Acids, Essential - metabolism, Membrane Proteins, Prostaglandin-Endoperoxide Synthases - metabolism

Add Comment 0 Comments

720 38


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

25 May 2023 : Database Analysis  

COVID-19 Crisis And The Study Of The Incidence Of Alcohol-related Deaths In Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

23 May 2023 : Database Analysis  

Association Between Alcohol Consumption and Cardiovascular Risk Based on Data from the Three Generations fo...

Med Sci Monit In Press; DOI: 10.12659/MSM.940327  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750