Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 August 2005

A randomized trial of prostaglandin E(2) gel and extra-amniotic saline infusionwith high dose oxytocin for cervical ripening.

Seyedeh-Hajar Sharami, Froozan Milani, Ziba Zahiri, Fariborz Mansour-Ghanaei

Med Sci Monit 2005; 11(8): CR381-386 :: ID: 201385

Abstract

Background: Our purpose was to compare the efficacy of extra-amniotic salineinfusion plus high dose oxytocin with prostaglandin E(2) intracervical gel (Dinoprostone) for preinductioncervical ripening. Material/Methods: 166 nulliparous women with term pregnancies, vertex presentation,intact membranes and a Bishop score (2) intracervical gel and extra-amniotic saline infusion (EASI) plushigh-dose oxytocin. Changes in the Bishop scores, labor progress, various labor end points and outcomesof labor were assessed. Data were analyzed using chi(2) analysis or the Student t-test. Results: 151women were studied after 15 exclusions, 75 were assigned to PGE(2), and 76 to EASI. The groups were similarin age, race, indication for induction and gestational age. The EASI group had a significant improvementin Bishop score and greater dilation. The mean time to vaginal delivery was 11.4+/-4.8 hours and 18.9+/-6.4hours for the EASI and PGE(2) groups respectively (P=0.001). The cesarean delivery rate was not significantlydifferent between the two groups (25% for the EASI group; 34.6% for the PGE(2) group). The cesarean ratedue to failure to progress, fetal labor intolerance, and maternal and neonatal outcomes were similarin the two groups. Conclusions: Preinduction cervical ripening with EASI plus high dose oxytocin resultedin greater changes in Bishop score, and shorter time to normal vaginal delivery than with PGE(2) gelin nulliparous women, without increasing the cesarean rate due to failure to progress or fetal laborintolerance.

Keywords: Cervical Ripening - drug effects, Amniotic Fluid, Cervical Ripening - drug effects, Dinoprostone - pharmacology, Gels, Infant, Newborn, Labor, Obstetric - drug effects, Oxytocin - pharmacology, Pregnancy, Pregnancy Outcome, Sodium Chloride - pharmacology

Add Comment 0 Comments

582 9

Editorial

01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

28 May 2023 : Database Analysis  

Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021

Med Sci Monit In Press; DOI: 10.12659/MSM.938715  

25 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750