01 August 2005
A randomized trial of prostaglandin E(2) gel and extra-amniotic saline infusionwith high dose oxytocin for cervical ripening.
Seyedeh-Hajar Sharami, Froozan Milani, Ziba Zahiri, Fariborz Mansour-GhanaeiMed Sci Monit 2005; 11(8): CR381-386 :: ID: 201385
Abstract
Background: Our purpose was to compare the efficacy of extra-amniotic salineinfusion plus high dose oxytocin with prostaglandin E(2) intracervical gel (Dinoprostone) for preinductioncervical ripening. Material/Methods: 166 nulliparous women with term pregnancies, vertex presentation,intact membranes and a Bishop score (2) intracervical gel and extra-amniotic saline infusion (EASI) plushigh-dose oxytocin. Changes in the Bishop scores, labor progress, various labor end points and outcomesof labor were assessed. Data were analyzed using chi(2) analysis or the Student t-test. Results: 151women were studied after 15 exclusions, 75 were assigned to PGE(2), and 76 to EASI. The groups were similarin age, race, indication for induction and gestational age. The EASI group had a significant improvementin Bishop score and greater dilation. The mean time to vaginal delivery was 11.4+/-4.8 hours and 18.9+/-6.4hours for the EASI and PGE(2) groups respectively (P=0.001). The cesarean delivery rate was not significantlydifferent between the two groups (25% for the EASI group; 34.6% for the PGE(2) group). The cesarean ratedue to failure to progress, fetal labor intolerance, and maternal and neonatal outcomes were similarin the two groups. Conclusions: Preinduction cervical ripening with EASI plus high dose oxytocin resultedin greater changes in Bishop score, and shorter time to normal vaginal delivery than with PGE(2) gelin nulliparous women, without increasing the cesarean rate due to failure to progress or fetal laborintolerance.
Keywords: Cervical Ripening - drug effects, Amniotic Fluid, Cervical Ripening - drug effects, Dinoprostone - pharmacology, Gels, Infant, Newborn, Labor, Obstetric - drug effects, Oxytocin - pharmacology, Pregnancy, Pregnancy Outcome, Sodium Chloride - pharmacology
582 9
Editorial
01 May 2023 : Editorial
Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor TherapyDOI: 10.12659/MSM.940911
Med Sci Monit 2023; 29:e940911
In Press
28 May 2023 : Database Analysis
Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021Med Sci Monit In Press; DOI: 10.12659/MSM.938715
25 May 2023 : Database Analysis
The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in PolandMed Sci Monit In Press; DOI: 10.12659/MSM.940904
25 May 2023 : Review article
A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...Med Sci Monit In Press; DOI: 10.12659/MSM.940635
25 May 2023 : Clinical Research
Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...Med Sci Monit In Press; DOI: 10.12659/MSM.940533
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952