Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

19 June 2002

Human Cytomegalovirus Infection and Abortion: an Immunohistochemical Study

Liliana Cruz Spano, Fausto Edmundo Lima Pereira, Nádia Gomes da Silva Basso, Paulo Roberto Mercon-de-Vargas

Med Sci Monit 2002; 8(6): BR230-235 :: ID: 420792

Abstract

BACKGROUND: Cytomegalovirus (HCMV) has been described in abortion tissues,but seldom associated with inclusion bodies. However, the possible pathogenic role of this virus in abortionis under discussion. We attempted to verify the relationship between HCMV antigens in tissues from firsttrimester abortions presenting with inflammatory lesions.MATERIAL/METHODS: Sixteen cases of first trimesterabortions with inflammatory lesions were selected from 340 cases studied at the Pathology Unit of theUniversity Hospital in Vit ria, Esp rito Santo State, Brazil. Paraffin-embedded sections were subjectedto indirect immunofluorescence (IFI) and immunoperoxidase (PAP), using monoclonal antibodies directedagainst immediate early (IEA) and late antigens (LA) of HCMV.RESULTS: Twelve out of sixteen cases (75%)presented at least one HCMV antigen. Eight cases presented both antigens, three cases only the IEA andone case only the LA. These antigens were present in decidual cells, in stromal cells of chorionic villiand in trophoblastic cells.CONCLUSIONS: The results showed high frequency of HCMV antigens in tissuesfrom first trimester abortion. This frequency, higher than that previously reported, was probably dueto the fact that necro-inflammatory lesions were always present in selected cases. The presence of LAin trophoblastic cells is evidence for cell permissiveness to viral replication in vivo. The resultsshowing high presence of HCMV antigens in tissues from abortion with inflammatory lesions suggest a possiblerelationship of HCMV infection with inflammation and pregnancy loss.

Keywords: Abortion, Spontaneous, Antibodies, Monoclonal, Antigens, Viral, Fluorescent Antibody Technique, Indirect, Pregnancy, Pregnancy Trimester, First

Add Comment 0 Comments

Editorial

01 April 2025 : Editorial  

Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to Humans

Dinah V. Parums

DOI: 10.12659/MSM.949109

Med Sci Monit 2025; 31:e949109

0:00

In Press

Review article  

A Review of Circulating Tumor DNA (ctDNA) and the Liquid Biopsy in Cancer Diagnosis, Screening, and Monitor...

Med Sci Monit In Press; DOI: 10.12659/MSM.949300  

0:00

Clinical Research  

Buccal Acupuncture Reduces the Dose of Sufentanil Needed in Laparoscopic Gynecological Surgery

Med Sci Monit In Press; DOI: 10.12659/MSM.947088  

0:00

Review article  

Global Guidelines and Trends in HPV Vaccination for Cervical Cancer Prevention

Med Sci Monit In Press; DOI: 10.12659/MSM.947173  

0:00

Clinical Research  

Serum Prolidase and Ischemia-Modified Albumin Levels in Neural Tube Defects: A Comparative Study of Myelome...

Med Sci Monit In Press; DOI: 10.12659/MSM.947873  

0:00

Most Viewed Current Articles

17 Jan 2024 : Review article   7,932,897

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   702,919

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   29,882

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   23,844

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750