Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

18 June 2002

Oxidative stress in the blood of patients with alcohol-related liver cirrhosis.

Jadwiga Daniluk, Agnieszka Szuster-Ciesielska, Martyna Kandefer-Szerszeń

Med Sci Monit 2002; 8(6): CR419-424 :: ID: 420815

Abstract

BACKGROUND: Ethanol may increase the production of reactive oxygen species(ROS) in the liver, which results in the development of alcoholic liver disease (ALD). Cytokine-activatedblood leukocytes may also participate in this process. The aim of our study was to evaluate the oxidativestress level in the blood of patients with alcoholic liver cirrhosis.MATERIAL/METHODS: Blood neutrophilsfrom 16 patients with compensated alcoholic liver cirrhosis and 28 patients with decompensated were evaluatedfor their ability to produce superoxide anion and hydrogen peroxide spontaneously and after PMA induction,in comparison to controls (16 healthy persons). Serum catalase (CAT), superoxide dismutase (SOD) andglutathione peroxidase (GPx) activity were also measured in both groups of patients and in the controls.RESULTS:The neutrophils from patients with compensated liver cirrhosis spontaneously produced a normal levelof O2*- and a high level of H2O2, but exhibited a defect in PMA-induced O2*- production. The neutrophilsfrom patients with decompensated liver cirrhosis spontaneously produced more O2*- and H2O2 than the controls,but the PMA response was weak. There were no changes in the expression of GPx, but enhanced SOD activitywas observed in the serum of patients with decompensated alcoholic liver cirrhosis. Increased CAT activitywas detected only in serum from patients with compensated liver cirrhosis.CONCLUSIONS: These data pointto oxidative stress in the blood of patients with decompensated alcoholic cirrhosis, since increasedresting production of ROS in neutrophils was not accompanied by increased GPx and CAT activity in serum.

Keywords: Liver Cirrhosis, Alcoholic

Add Comment 0 Comments

Editorial

01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315

0:00

In Press

Clinical Research  

Trust and Support for Cancer Research Biobanks: Insights from Cancer Patients in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.944263  

Clinical Research  

Morphological and Dimensional Analysis of the Nasopalatine Canal: Insights from Cone-Beam Computed Tomograp...

Med Sci Monit In Press; DOI: 10.12659/MSM.944424  

Clinical Research  

Hemorrhagic Cysts in the Pancreas: Risk Factors, Treatment, and Outcomes – Insights from a Single-Center Study

Med Sci Monit In Press; DOI: 10.12659/MSM.941955  

Clinical Research  

Perioperative Administration of Tranexamic Acid and Low Molecular Weight Heparin for Enhanced Blood Managem...

Med Sci Monit In Press; DOI: 10.12659/MSM.944063  

Most Viewed Current Articles

14 Dec 2022 : Clinical Research   1,421,178

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

17 Jan 2024 : Review article   1,355,487

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   690,090

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,113

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750