18 June 2002
Oxidative stress in the blood of patients with alcohol-related liver cirrhosis.
Jadwiga Daniluk, Agnieszka Szuster-Ciesielska, Martyna Kandefer-SzerszeńMed Sci Monit 2002; 8(6): CR419-424 :: ID: 420815
Abstract
BACKGROUND: Ethanol may increase the production of reactive oxygen species(ROS) in the liver, which results in the development of alcoholic liver disease (ALD). Cytokine-activatedblood leukocytes may also participate in this process. The aim of our study was to evaluate the oxidativestress level in the blood of patients with alcoholic liver cirrhosis.MATERIAL/METHODS: Blood neutrophilsfrom 16 patients with compensated alcoholic liver cirrhosis and 28 patients with decompensated were evaluatedfor their ability to produce superoxide anion and hydrogen peroxide spontaneously and after PMA induction,in comparison to controls (16 healthy persons). Serum catalase (CAT), superoxide dismutase (SOD) andglutathione peroxidase (GPx) activity were also measured in both groups of patients and in the controls.RESULTS:The neutrophils from patients with compensated liver cirrhosis spontaneously produced a normal levelof O2*- and a high level of H2O2, but exhibited a defect in PMA-induced O2*- production. The neutrophilsfrom patients with decompensated liver cirrhosis spontaneously produced more O2*- and H2O2 than the controls,but the PMA response was weak. There were no changes in the expression of GPx, but enhanced SOD activitywas observed in the serum of patients with decompensated alcoholic liver cirrhosis. Increased CAT activitywas detected only in serum from patients with compensated liver cirrhosis.CONCLUSIONS: These data pointto oxidative stress in the blood of patients with decompensated alcoholic cirrhosis, since increasedresting production of ROS in neutrophils was not accompanied by increased GPx and CAT activity in serum.
Keywords: Glutathione Peroxidase, Liver Cirrhosis, Alcoholic
783 6
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
08 Dec 2023 : Clinical Research
Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...Med Sci Monit In Press; DOI:
04 Dec 2023 : Animal Research
Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...Med Sci Monit In Press; DOI:
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292