Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

18 June 2002

Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice.

Walter T Hughes, Helieh S Oz, Elaine K Thomas, Craig J McClain

Med Sci Monit 2002; 8(6): BR208-211 :: ID: 420822


BACKGROUND: Patients who recover from acute trypanosomiasis may succumbto chronic Chagas' disease later in life due to age related immunosuppression, immune system disorderssuch as AIDS, or during periods of immunosuppressive therapy for organ transplantation. In this study,effects of immunomodulators with diverse properties were examined on the course of an acute and lethalTrypanosoma cruzi infection.MATERIAL/METHODS: ICR (Swiss) mice inoculated with Tulahuen (lethal) strainof T. cruzi were treated with 6 different immunomodulators and the course of infection was studied.RESULTS:Tacrolimus (FK-506) and dexamethasone increased parasitemia in mice when compared to infected untreatedanimals. Mycophenolate mofetil (RS-61443) and recombinant interleukin-15 (IL-15) treatment decreasedthe number of parasites but had no effect on animal survival. In contrast, compound L-685-818 (tacrolimusanalog) and CD40 ligand (CD40L), provided protection against lethal infection. Mice that survived initialinfection were all protected against reinfection.CONCLUSIONS: This study demonstrates the dangers ofimmunosuppression with tacrolimus and dexamethasone in T. cruzi infected subjects. While mycophenolatedid not exacerbate the infection, our data suggest potential therapeutic applications for L-685-818 andCD40 ligand in trypanosomiasis.

Keywords: Adjuvants, Immunologic, CD40 Ligand, Dexamethasone, Immunosuppressive Agents, Interleukin-15, Mice, Inbred ICR, Mycophenolic Acid, Research Support, Non-U.S. Gov, Research Support, U.S. Gov, Research Support, U.S. Gov, Tacrolimus, Trypanosoma cruzi, Trypanosomiasis

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Clinical Research  

Trust and Support for Cancer Research Biobanks: Insights from Cancer Patients in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.944263  

Clinical Research  

Morphological and Dimensional Analysis of the Nasopalatine Canal: Insights from Cone-Beam Computed Tomograp...

Med Sci Monit In Press; DOI: 10.12659/MSM.944424  

Clinical Research  

Hemorrhagic Cysts in the Pancreas: Risk Factors, Treatment, and Outcomes – Insights from a Single-Center Study

Med Sci Monit In Press; DOI: 10.12659/MSM.941955  

Clinical Research  

Perioperative Administration of Tranexamic Acid and Low Molecular Weight Heparin for Enhanced Blood Managem...

Med Sci Monit In Press; DOI: 10.12659/MSM.944063  

Most Viewed Current Articles

14 Dec 2022 : Clinical Research   1,421,178

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


17 Jan 2024 : Review article   1,355,487

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


16 May 2023 : Clinical Research   690,090

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,113

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750