18 June 2002
Effect of anti-oxidants, free radical quenchers and cyclo-oxygenase inhibitoron benzo(a)pyrene-induced suppression of human lymphocyte mitogenesis in vitro.
Undurti N DasMed Sci Monit 2002; 8(6): BR205-207 :: ID: 420823
Abstract
BACKGROUND: Benzo(a)pyrene (BP) is a known carcinogen and immunosuppressor.Activation of BP to its reactive intermediates is cyclo-oxygenase (COX) dependent and occurs via a freeradical dependent mechanism. The aim of this study was to know whether anti-oxidants, free radical quenchersand (COX) inhibitor, indomethacin, influence the suppression of human T cells induced by BP in vitro.MATERIAL/METHODS:Human lymphocytes, obtained from healthy human volunteers, were stimulated to proliferate using phytohaemagglutinin(PHA). The effect of vitamin E, SOD, catalase, mannitol, and COX-inhibitor, indomethacin, on BP-inducedsuppression of human T cell proliferation was evaluated.RESULTS: Except for catalase, a hydrogen peroxide(H2O2) radical quencher, none of the agents tested could inhibit BP-induced suppression of human T cellproliferation in vitro.CONCLUSIONS: BP-induced suppression of human T cell proliferation is probably,induced by increased production of H2O2. Prostaglandins and superoxide anion and hydroxyl radical donot seem to participate in BP-induced human T cell growth suppression.
Keywords: Benzo(a)pyrene, Cyclooxygenase Inhibitors, Free Radical Scavengers, Lymphocytes
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952