Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

15 May 2002

Hepatitis B vaccine immunogenicity in patients with chronic HCV infection atone year follow-up: the effect of interferon-alpha therapy.

Sławomir Chlabicz, Anna Grzeszczuk, Tadeusz Wojciech Łapiński

Med Sci Monit 2002; 8(5): CR379-383 :: ID: 420833

Abstract

BACKGROUND: Patients with chronic hepatitis C are at risk of additionalliver damage when infected with other hepatotropic viruses, and should be vaccinated against HAV andHBV. However, the optimal dose and schedule are still being debated. In this study we assessed hepatitisB vaccine immunogenicity in patients with chronic hepatitis C at one-year follow-up. The effect of interferonalpha treatment on vaccine safety and anti-HBs response was also evaluated. MATERIAL/METHODS: 48 hepatitisC patients were enrolled, of whom 12 were on interferon treatment. Recombinant HBV vaccine was administeredon a 0-1-6 month schedule, and anti-HBs titers were measured at months 1, 2, 7, and 18. RESULTS: Theoverall seroprotection rate at month 7 was 72.9% in hepatitis C patients, compared to 90.9% in the controls.Subjects with chronic hepatitis C had significantly lower percentages of good responders: 50% versus90.9%. At month 18, only 34.1% of the HCV patients had seroprotective titers of anti-HBs, compared to90% in the control group. At all study points there were no significant differences in seroconversionrates and seroprotection rates between subgroups of hepatitis C patients receiving interferon or thosewithout antiviral treatment. CONCLUSIONS: Hepatitis C is associated with decreased HBV vaccine response.We suggest that postvaccination anti-HBs testing should be performed in all hepatitis C patients, andadditional vaccine doses should be provided to those without protection. Alternatively, higher dosesof vaccine (40 Kg) may be considered. Treatment with interferon was safe and well tolerated.

Keywords: Hepacivirus, Hepatitis B Antibodies, Hepatitis B Vaccines, Hepatitis C, Hepatitis C Antibodies, Interferon-alpha, Interferons, Liver, Recombinant Proteins, Time Factors

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Clinical Research  

Clinical Outcomes of Talus Bone Marrow Edema: Comparing Plaster Cast, Crutches, and Walking Boot Treatments

Med Sci Monit In Press; DOI: 10.12659/MSM.946072  

0:00

Review article  

Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and Pharmacokinetics

Med Sci Monit In Press; DOI: 10.12659/MSM.945582  

Clinical Research  

Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...

Med Sci Monit In Press; DOI: 10.12659/MSM.944912  

Clinical Research  

Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...

Med Sci Monit In Press; DOI: 10.12659/MSM.946265  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,335,406

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,908,931

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,409

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,542

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750