11 March 2002
Asthma and gastroesophageal reflux in children.
Krystyna Wasowska-Królikowska, Ewa Toporowska-Kowalska, Aneta KrogulskaMed Sci Monit 2002; 8(3): RA64-71 :: ID: 420895
Abstract
Gastroesophageal reflux (GER) is a factor often neglected in the etiopathogenesisof asthma. The estimated incidence of GER in asthmatic children reaches 50-60% and is higher than inthe general population. GER may accompany typical symptoms: hoarseness, sore throat, thoracic pain, coughor wheezing. GER may not only aggravate the course of bronchial obstruction, but may also cause it, ortrigger obstruction due to other factors. Asthma and GER coincidence has been acknowledged for many years.The paper presents a current review of studies concerning the relations between asthma and GER and attemptsto establish, which is the cause and which is the result. The hypotheses how GER can lead to bronchialobstruction, and how obstruction can aggravate GER, are also presented. GER is believed to be a factorcausing obstruction by: 1. an indirect mechanism - reflex theory, 2. a direct mechanism - reflux theory,and 3. a neuropeptide-mediated mechanism. The paper also presents diagnostic methods allowing to detectGER in asthmatics. A review of recent studies concerning the treatment of GER in asthmatics, both withpharmacological and surgical methods, is also included. Beneficial effect of antireflux therapy on thecourse of asthma has been emphasized. Therefore, antireflux therapy is recommended in all patients withconcurrent asthma and GER, irrespective of severity of clinical GER symptoms, even in those with silentGER. The essential drugs used in the treatment of GER are proton pump inhibitors. Appropriately highdose level and appropriately long duration of the therapy should be taken into consideration.
Keywords: Adolescent, Asthma, Child, Child, Preschool, Diagnosis, Differential, Gastroesophageal Reflux
Editorial
01 January 2026 : Editorial
Editorial: Increasing Awareness of Lung Cancer in Non-Smokers and Never-Smokers Challenges Current Approaches to Prevention and ScreeningDOI: 10.12659/MSM.952454
Med Sci Monit 2026; 32:e952454
In Press
Clinical Research
Institutional and Regional Variations in Access to Clinical Trials and Next-Generation Sequencing in Turkis...Med Sci Monit In Press; DOI: 10.12659/MSM.951027
Clinical Research
Low-Intensity Blood Flow-Restricted Multi-Joint Exercise Improves Muscle Function in Patients With Patellof...Med Sci Monit In Press; DOI: 10.12659/MSM.950516
Review article
Musculoskeletal Ultrasound and MRI in the Evaluation of Chemotherapy-Induced Peripheral Neuropathy: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.951283
Clinical Research
Sensory Processing, Dissociation, and Affective Symptoms in Misophonia: A Cross-Sectional Study of 35 AdultsMed Sci Monit In Press; DOI: 10.12659/MSM.950938
Most Viewed Current Articles
17 Jan 2024 : Review article 10,187,196
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
13 Nov 2021 : Clinical Research 3,708,487
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
14 Dec 2022 : Clinical Research 2,341,643
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 706,524
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387






