11 March 2002
Asthma and gastroesophageal reflux in children.
Ewa Toporowska-Kowalska, Krystyna Wasowska-Królikowska, Aneta KrogulskaMed Sci Monit 2002; 8(3): RA64-71 :: ID: 420895
Abstract
Gastroesophageal reflux (GER) is a factor often neglected in the etiopathogenesisof asthma. The estimated incidence of GER in asthmatic children reaches 50-60% and is higher than inthe general population. GER may accompany typical symptoms: hoarseness, sore throat, thoracic pain, coughor wheezing. GER may not only aggravate the course of bronchial obstruction, but may also cause it, ortrigger obstruction due to other factors. Asthma and GER coincidence has been acknowledged for many years.The paper presents a current review of studies concerning the relations between asthma and GER and attemptsto establish, which is the cause and which is the result. The hypotheses how GER can lead to bronchialobstruction, and how obstruction can aggravate GER, are also presented. GER is believed to be a factorcausing obstruction by: 1. an indirect mechanism - reflex theory, 2. a direct mechanism - reflux theory,and 3. a neuropeptide-mediated mechanism. The paper also presents diagnostic methods allowing to detectGER in asthmatics. A review of recent studies concerning the treatment of GER in asthmatics, both withpharmacological and surgical methods, is also included. Beneficial effect of antireflux therapy on thecourse of asthma has been emphasized. Therefore, antireflux therapy is recommended in all patients withconcurrent asthma and GER, irrespective of severity of clinical GER symptoms, even in those with silentGER. The essential drugs used in the treatment of GER are proton pump inhibitors. Appropriately highdose level and appropriately long duration of the therapy should be taken into consideration.
Keywords: Adolescent, Asthma, Child, Child, Preschool, Diagnosis, Differential, Gastroesophageal Reflux
Editorial
04 June 2022 : Editorial
Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?DOI: 10.12659/MSM.937371
Med Sci Monit 2022; 28:e937371
SARS-CoV-2/COVID-19
30 June 2022 : Editorial
Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Respo...Med Sci Monit In Press; DOI: 10.12659/MSM.937676
27 June 2022 : Clinical Research
Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...Med Sci Monit In Press; DOI: 10.12659/MSM.937430
04 June 2022 : Clinical Research
Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...Med Sci Monit 2022; 28:e936962
30 May 2022 : Clinical Research
Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...Med Sci Monit 2022; 28:e936069
In Press
30 Jun 2022 : Laboratory Research
Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...Med Sci Monit In Press; DOI: 10.12659/MSM.936760
30 Jun 2022 : Editorial
Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Respo...Med Sci Monit In Press; DOI: 10.12659/MSM.937676
30 Jun 2022 : Clinical Research
Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip ArthroplastyMed Sci Monit In Press; DOI: 10.12659/MSM.936335
28 Jun 2022 : Meta-Analysis
Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-AnalysisMed Sci Monit In Press; DOI: 10.12659/MSM.937166
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952