Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

11 March 2002

Assessment of correlation between the presence of antiendomysial antibodiesand small intestine mucosal villous atrophy in the diagnostics of celiac disease.

Anna Szaflarska-Szczepanik

Med Sci Monit 2002; 8(3): CR185-188 :: ID: 420905

Abstract

BACKGROUND: The aim of the study was to analyze the degree of correlationbetween the presence of serum antiendomysial antibodies and villous atrophy in small intestine mucosain patients with celiac disease. MATERIAL/METHODS: Retrospective analysis carried out in a group of 88children and young adults (28 males, 60 females aged from 2 to 23) hospitalized in the Clinic from 1990to the present with positive results of serum antiendomysial antibody test performed because of suspectedceliac disease. The IgA - EmA test was performed after determination of whole IgA level in the serumusing indirect immunofluorescence technique with monkey esophagus as an antigen. All patients underwentendoscopic small intestine biopsy with histopathological assessment of mucosal bioptates using standardhematoxylin and eosin staining. RESULTS: The serum levels of IgA in all investigated patients were normal.The levels of antiendomysial antibodies expressed in IF units ranged from 10 to 40960. Histopathologicalassessment of small intestine mucosal bioptates revealed partial (in 13.6% of patients) or total (in86.4% of patients) villous atrophy. CONCLUSIONS: The study demonstrated complete correlation betweenthe presence of serum antiendomysial antibodies and villous atrophy in the small intestine mucosa.

Keywords: Adolescent, Biological Markers, celiac disease, Child, Child, Preschool, Immunoglobulin A, Intestinal Mucosa, Intestine, Small

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

15 Jan 2024 : Clinical Research  

Comparison of Modified Shock Index and Shock Index for Predicting Massive Transfusion in Women with Primary...

Med Sci Monit In Press; DOI: 10.12659/MSM.943286  

0:00

15 Jan 2024 : Database Analysis  

Bibliometric Analysis of Brain Stimulation Technologies in Sleep Disorders

Med Sci Monit In Press; DOI: 10.12659/MSM.942687  

15 Jan 2024 : Clinical Research  

Clinical Outcomes of Arthroscopic Surgery in Patients with Gluteal Muscle Contracture: Single-Institution R...

Med Sci Monit In Press; DOI: 10.12659/MSM.942945  

17 Jan 2024 : Laboratory Research  

Impact of Auxiliary Features on Retention of Short Dental Crowns: An In-Vitro Analysis of Box and Groove Pr...

Med Sci Monit In Press; DOI: 10.12659/MSM.943401  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750