11 March 2002
Assessment of correlation between the presence of antiendomysial antibodiesand small intestine mucosal villous atrophy in the diagnostics of celiac disease.
Anna Szaflarska-SzczepanikMed Sci Monit 2002; 8(3): CR185-188 :: ID: 420905
Abstract
BACKGROUND: The aim of the study was to analyze the degree of correlationbetween the presence of serum antiendomysial antibodies and villous atrophy in small intestine mucosain patients with celiac disease. MATERIAL/METHODS: Retrospective analysis carried out in a group of 88children and young adults (28 males, 60 females aged from 2 to 23) hospitalized in the Clinic from 1990to the present with positive results of serum antiendomysial antibody test performed because of suspectedceliac disease. The IgA - EmA test was performed after determination of whole IgA level in the serumusing indirect immunofluorescence technique with monkey esophagus as an antigen. All patients underwentendoscopic small intestine biopsy with histopathological assessment of mucosal bioptates using standardhematoxylin and eosin staining. RESULTS: The serum levels of IgA in all investigated patients were normal.The levels of antiendomysial antibodies expressed in IF units ranged from 10 to 40960. Histopathologicalassessment of small intestine mucosal bioptates revealed partial (in 13.6% of patients) or total (in86.4% of patients) villous atrophy. CONCLUSIONS: The study demonstrated complete correlation betweenthe presence of serum antiendomysial antibodies and villous atrophy in the small intestine mucosa.
Keywords: Adolescent, Biological Markers, celiac disease, Child, Child, Preschool, Immunoglobulin A, Intestinal Mucosa, Intestine, Small
Editorial
01 February 2025 : Editorial
Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-SmokersDOI: 10.12659/MSM.948255
Med Sci Monit 2025; 31:e948255
In Press
Clinical Research
Immune Dysregulation in Acute Herpes Zoster: Predictive Factors for Postherpetic NeuralgiaMed Sci Monit In Press; DOI: 10.12659/MSM.944688
Clinical Research
Inflammatory Biomarkers from Blood Counts as Prognostic Tools in Metastatic Esophageal CancerMed Sci Monit In Press; DOI: 10.12659/MSM.947202
Laboratory Research
Comparison of Color Stability Between Single-Shade and Conventional Composite Resins Following Immersion in...Med Sci Monit In Press; DOI: 10.12659/MSM.946784
Clinical Research
Evaluation of Knowledge, Attitudes, and Practices Toward Thyroid Nodules in 456 Patients with Thyroid NodulesMed Sci Monit In Press; DOI: 10.12659/MSM.945732
Most Viewed Current Articles
17 Jan 2024 : Review article 6,966,841
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research 701,694
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Mar 2024 : Editorial 25,087
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...DOI :10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
28 Jan 2024 : Review article 19,746
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and FutureDOI :10.12659/MSM.943912
Med Sci Monit 2024; 30:e943912