Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

11 March 2002

Circulating oxidized LDL is associated with increased levels of cell-adhesionmolecules in clinically healthy 58-year old men (AIR study).

Johannes Hulthe, Björn Fagerberg

Med Sci Monit 2002; 8(3): CR148-152 :: ID: 420912


BACKGROUND: Inflammation has been postulated to play an important rolein atherosclerosis development. Recently, research in this field has been focused on the role of modifiedlipoproteins, primarily oxidized low density lipoprotein. Adhesion and transendothelial migration ofcirculating leukocytes, by the action of cell-adhesion molecules, seem to be critical steps in earlyatherogenesis. Previous in vitro studies on the relationship between ox-LDL and the expression of cell-adhesionmolecules on endothelial cells have shown diverging results. Furthermore, there are as yet no reportson the relationship between circulating ox-LDL and cell-adhesion molecules in vivo. MATERIAL/METHODS:The relationship between circulating ox-LDL and adhesion molecules was measured by ELISA in clinicallyhealthy, 58-year-old men recruited from the general population (n=391). RESULTS: The results of the presentstudy showed that circulating ox-LDL was associated with sICAM-1 and sE-selectin, but not with sVCAM-1.After adjustment for other risk factors, i.e. systolic blood pressure, LDL cholesterol, apoB, apoA1 andsmoking, the observed relationships between ox-LDL and sICAM-1 and sE-selectin, respectively, remainedstatistically significant. CONCLUSIONS: The observed results fit into the concept that oxidatively modifiedLDL may regulate the increased expression of cell-adhesion molecules on endothelial cells in vivo. Theseobservations were made in a population-based sample of clinically healthy, middle-aged Caucasian men.Since this was a cross-sectional study no conclusions can be drawn on causality.

Keywords: Cell Adhesion, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Lipoproteins, LDL, Regression Analysis, Research Support, Non-U.S. Gov

Add Comment 0 Comments

469 2


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

28 May 2023 : Database Analysis  

Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021

Med Sci Monit In Press; DOI: 10.12659/MSM.938715  

25 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750