Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

25 February 2002

Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats.

Ji-Yao Wang, Chi Zhang, Jian-Jun Liu, Ake Nilsson, Rui-Dong Duan

Med Sci Monit 2002; 8(2): BR56-60 :: ID: 420918


BACKGROUND: Renal failure in cirrhotic patients is a severe complicationand endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhoticrats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosiswas generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted byendotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen(BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a)were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosinstaining. RESULTS: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats,with a much higher elevation in the latter group. TNF-a concentration was also increased by endotoxin;the changes are positively correlated with BUN and creatinine. NAC pretreatment significantly attenuatesthe effects of endotoxin on BUN, creatinine and TNF-a levels in cirrhotic rats with no improvement insystemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals.CONCLUSIONS: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which maybe protected by NAC.

Keywords: Acetylcysteine, Endotoxins, Kidney, Liver Cirrhosis

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Database Analysis  

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatini...

Med Sci Monit In Press; DOI: 10.12659/MSM.943063  

Database Analysis  

Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern...

Med Sci Monit In Press; DOI: 10.12659/MSM.943601  

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  

Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750