Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

22 February 2002

Total IgE levels in children under three years of age.

Maciej Kaczmarski, Elzbieta Malinowska

Med Sci Monit 2002; 8(2): CR113-118 :: ID: 420930


BACKGROUND: The course of type 1 allergic reaction is a result of compleximmune processes in which immunoglobulin E plays a crucial role. The serum level of this immunoglobulin(IgE(total)) is closely related to the age of the patient. The presented paper analyses IgE(total) inchildren below 3. MATERIAL/METHODS: The study was carried out in group of 291 patients aged 5-39 months.IgE(total) were determined using the Fluoro-FAST 3M. The analysis took into consideration the age, sexand living place of the examined children. RESULTS: The artmetic mean of IgE(total) was 38.8 +/- 4.0IU/ml, the median--12 IU/ml, whereas the 5th and 95th percentile values amounted to 1IU/ml and 185 IU/ml,respectively. According to the standards recommended by the manufacturer of reagents used for determinationof IgE(total) (Bio Whittaker), 103 children (35.4%) had elevated serum levels of IgE(total), whereas196 (67.4%) were found to have elevated IgE(total) according to population standards. The obtained percentagedistribution of elevated IgE(total) values in particular age groups is characterized by stepwise changes,observed in the age intervals for which the range of values considered as normal by the manufactureris changed. CONCLUSIONS: On the basis of analyzed IgE(total) determinations it has been established thatthe manufacturer's standards for children aged from 2 to 3 years are overestimated, whereas the populationstandards seem to be underestimated. Therefore, the determination of IgE(total) normal value range requiresfurther studies.

Keywords: Hypersensitivity, Immunoglobulin E, Sensitivity and Specificity

Add Comment 0 Comments

508 12


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911


In Press

31 May 2023 : Review article  

Prevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939919  

30 May 2023 : Clinical Research  

A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...

Med Sci Monit In Press; DOI: 10.12659/MSM.940409  

30 May 2023 : Review article  

A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...

Med Sci Monit In Press; DOI: 10.12659/MSM.940550  

30 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750