Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

22 February 2002

Antiapoptotic effect of (-)-deprenyl in rat kidney after ischemia-reperfusion.

Eva Toronyi, János Hamar, Kálmán Magyar, Béla Szende

Med Sci Monit 2002; 8(2): BR65-68 :: ID: 420945


BACKGROUND: Since apoptosis of renal tubular cells is the basis of thedamage caused by ischaemia-reperfusion, the antiapoptotic effect on kidney tubular epithelial cells ofthe monoamino oxidase-B (MAO-B) inhibitor (-) deprenyl (selegiline), known neuroprotective agent, withantiapoptotic properties, was studied in a rat model. MATERIAL/METHODS: Warm renal ischaemia was causedby clamping the left renal artery of rats for 30 minutes. With the start of reperfusion 0.015 mg/kg,0.15 mg/kg and 1.5 mg/kg of (-)-deprenyl was injected simultaneously into the carotid artery of the animals,respectively. Five rats served as control, in which renal artery clamping was performed, but the ratswere only treated with the solvent (physiological saline). After 6 hours of reperfusion the rats wereexsanguinated and the kidneys were histologically examined. RESULTS: Severe tubular damage characterisedby apoptosis was found in the kidneys of the untreated rats. Apoptosis was verified on the basis of morphologicalfeatures, methylgreen-pyronin staining and TUNEL reaction. (-)-Deprenyl diminished dose-dependently theapoptotic damage, 0.15 mg/kg being the most effective dose. The same dose of (-)-Deprenyl is used inthe therapy of human Parkinson's disease. CONCLUSIONS: Our findings suggest, that (-)-deprenyl mighthave an impact on decreasing renal injury also in case of human cadaveric renal transplantation.

Keywords: In Situ Nick-End Labeling, Kidney, Monoamine Oxidase Inhibitors, Rats, Wistar, Research Support, Non-U.S. Gov, selegiline

Add Comment 0 Comments

736 5


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

08 Dec 2023 : Clinical Research  

Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...

Med Sci Monit In Press; DOI:  

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750