Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

09 January 2002

Soluble cytokine receptors in renal vasculitis and lupus nephritis.

Vladimír Tesar, Milan Jirsa, Tomás Zima, Marta Kalousová, Jirina Bartunková, Alena Stejskalová, Ctibor Dostál, Jiri Zabka

Med Sci Monit 2002; 8(1): BR24-29 :: ID: 420974


BACKGROUND: The activation of various cytokines, e.g. TNFalpha, IL-1 and/orIL-6, may play an important role in the pathogenesis of renal vasculitis and lupus nephritis (LN). Thesystemic effect of these cytokines may be modulated by their circulating soluble receptors. The plasmalevels of cytokine receptors may thus also be markers of the activation of these cytokines. MATERIAL/METHODS:The plasma levels of TNFalpha, its soluble receptor p75 (sTNF-RII), IL-6, and the soluble IL-6 receptor(sIL-6R) were measured using ELISA in 17 patients with ANCA-positive renal vasculitis (12 active - ANCA-A,7 in remission ANCA-R), 9 patients with active lupus nephritis (LN), and 5 healthy subjects. RESULTS:Patients with LN had increased plasma levels of TNFalpha, sTNF-RII, IL-6 and sIL-6R in comparison withcontrols. Patients with ANCA-A also had increased plasma levels of TNFalpha, sTNF-RII and sIL-6R in comparisonwith controls, but the increase in the plasma level of IL-6 was not statistically significant, due tothe large standard deviation. Patients with ANCA-R had increased plasma levels of sTNF-RII in comparisonto controls, but the plasma levels of TNFalpha were significantly lower in ANCA-R than in ANCA-A. Whilethe ratio of TNFalpha to sTNF-RII was significantly lower in all groups of patients than in the controls,the ratio of IL-6 to sIL-6R was significantly increased only in LN in comparison to controls. CONCLUSIONS:While increased plasma levels of TNFalpha may be a nonspecific marker of the activity of ANCA-positiverenal vasculitis and LN, plasma levels of sTNF-RII are also increased in patients with ANCA-positiverenal vasculitis in remission. Increased plasma levels of sTNF-RII may inhibit the systemic effects ofTNFalpha, but may also prolong the half-life of its active form. Plasma levels of sIL-6R are increasedboth in ANCA-A and in LN, but their increase is much less pronounced than that of sTNF-RII and cannoteffectively block the systemic effects of IL-6.

Keywords: Antigens, CD, Enzyme-Linked Immunosorbent Assay, Interleukin-6, Kidney Diseases, lupus nephritis, Receptors, Cytokine, Receptors, Interleukin-6, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type II, Research Support, Non-U.S. Gov, Vasculitis

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Review article  

Impact of Workplace Bullying on Nursing Care Quality: A Comprehensive Review

Med Sci Monit In Press; DOI: 10.12659/MSM.944815  

Clinical Research  

Anterior Plate-Supported Cannulated Screw Surgery for Ankle Arthrodesis: Clinical and Radiologic Results in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944452  

Clinical Research  

Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipo...

Med Sci Monit In Press; DOI: 10.12659/MSM.944462  

Database Analysis  

Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated A...

Med Sci Monit In Press; DOI: 10.12659/MSM.943414  

Most Viewed Current Articles

17 Jan 2024 : Review article   2,048,648

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,553,068

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   690,454

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,367

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750