Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

09 January 2002

Soluble cytokine receptors in renal vasculitis and lupus nephritis.

Vladimír Tesar, Milan Jirsa, Tomás Zima, Marta Kalousová, Jirina Bartunková, Alena Stejskalová, Ctibor Dostál, Jiri Zabka

Med Sci Monit 2002; 8(1): BR24-29 :: ID: 420974


BACKGROUND: The activation of various cytokines, e.g. TNFalpha, IL-1 and/orIL-6, may play an important role in the pathogenesis of renal vasculitis and lupus nephritis (LN). Thesystemic effect of these cytokines may be modulated by their circulating soluble receptors. The plasmalevels of cytokine receptors may thus also be markers of the activation of these cytokines. MATERIAL/METHODS:The plasma levels of TNFalpha, its soluble receptor p75 (sTNF-RII), IL-6, and the soluble IL-6 receptor(sIL-6R) were measured using ELISA in 17 patients with ANCA-positive renal vasculitis (12 active - ANCA-A,7 in remission ANCA-R), 9 patients with active lupus nephritis (LN), and 5 healthy subjects. RESULTS:Patients with LN had increased plasma levels of TNFalpha, sTNF-RII, IL-6 and sIL-6R in comparison withcontrols. Patients with ANCA-A also had increased plasma levels of TNFalpha, sTNF-RII and sIL-6R in comparisonwith controls, but the increase in the plasma level of IL-6 was not statistically significant, due tothe large standard deviation. Patients with ANCA-R had increased plasma levels of sTNF-RII in comparisonto controls, but the plasma levels of TNFalpha were significantly lower in ANCA-R than in ANCA-A. Whilethe ratio of TNFalpha to sTNF-RII was significantly lower in all groups of patients than in the controls,the ratio of IL-6 to sIL-6R was significantly increased only in LN in comparison to controls. CONCLUSIONS:While increased plasma levels of TNFalpha may be a nonspecific marker of the activity of ANCA-positiverenal vasculitis and LN, plasma levels of sTNF-RII are also increased in patients with ANCA-positiverenal vasculitis in remission. Increased plasma levels of sTNF-RII may inhibit the systemic effects ofTNFalpha, but may also prolong the half-life of its active form. Plasma levels of sIL-6R are increasedboth in ANCA-A and in LN, but their increase is much less pronounced than that of sTNF-RII and cannoteffectively block the systemic effects of IL-6.

Keywords: Antigens, CD, Enzyme-Linked Immunosorbent Assay, Interleukin-6, Kidney Diseases, lupus nephritis, Receptors, Cytokine, Receptors, Interleukin-6, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type II, Research Support, Non-U.S. Gov, Vasculitis

Add Comment 0 Comments

840 6


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750