Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 2001

Effect of sevoflurane on intracranial pressure and cardiovascular functionin rabbits with experimental intracerebral haematoma.

Zbigniew Karwacki, Przemysław Kowiański, Janusz Moryś, Jerzy Dziewiątkowski, Ewa Kaczmarek, Janina Suchorzewska

Med Sci Monit 2001; 7(2): BR212-217 :: ID: 421161


BACKGROUND: Sevoflurane is one of the newest volatile anaesthetic agents.The effect of sevoflurane on ICP in conditions of intracranial pathology is essential from the clinicalpoint of view but still not sufficiently clear. The aim of the study was to examine the effects of 1MAC, 2 MAC, 3 MAC sevoflurane on intracranial pressure (ICP), mean arterial blood pressure (MABP) andheart rate (HR) in rabbits with experimental intracerebral haematoma (ICH).
MATERIAL AND METHODS: Theexperiments were performed in 13 adult rabbits, 3.5-4.0 kg weight. The rabbits were randomly allocatedto two different groups. In group I, (n = 7), sevoflurane was administered in stepwise increasing concentrationsof 2.2 vol%, 4.4 vol% and 6.6 vol%, each for a period of 15 minutes. In group II (n = 6), intracerebralhaematoma was produced and subsequently sevoflurane was administered in the same manner as in group I.Ventilation parameters, inspiratory and end-tidal sevoflurane concentration, end-tidal CO2 concentration(ETCO2), HR, MABP, ICP and body temperature, measured in the nasopharynx, were monitored throughout theexperiment.
RESULTS: Mean values of ETCO2 and temperature in the nasopharynx were not significantly differentin both groups and remained stable in the whole observation period. In group II in all cases the evidenceof intraventricular haematoma was observed. In this group mean values of ICP, MABP and HR after haematomaproduction were significantly higher than those in group I. Statistically significant increase of ICPwas observed in 30th minute in group I, while in 35th minute in group II. In both groups a statisticallysignificant decrease in MABP was observed from 20th minute of observation. A significant decrease inHR in both groups from 25th minute of experiment was also observed.
CONCLUSION: In conclusion it shouldbe stressed that sevoflurane, in doses not exceeding 1 MAC, shows no significant effect on ICP and cardiovascularfunction in the course of intracranial haematoma.

Keywords: intracranial hemorrhage, Intracranial Pressure, rabbit, sevoflurane

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

07 May 2024 : Clinical Research  

Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944553  

16 Mar 2024 : Clinical Research  

Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...

Med Sci Monit In Press; DOI: 10.12659/MSM.943228  

08 May 2024 : Clinical Research  

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944022  

21 Mar 2024 : Clinical Research  

Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...

Med Sci Monit In Press; DOI: 10.12659/MSM.943249  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750