Abnormalities of glucose metabolism are a common feature of acromegaly.Overt diabetes mellitus develops in about 10-15% of patients. We present an unusual complication of acromegaly:a 37-year old man with a 2-year history of acromegaly developed diabetic ketoacidosis 3 weeks after transsphenoidaladenomectomy. No specific cause for this sudden metabolic derangement could be demonstrated. Insulinneed was very high in the first days after the onset of ketoacidosis, but was considerably reduced afterinitiation of treatment with octreotide and after successful re-operation.

Keywords: Diabetic Ketoacidosis, Insulin Resistance, acromegaly