Abstract

The purpose of this study was to evaluate the intensity of gastric inflammatorychanges in atopic patients infected with H. pylori, and to find out whether a long-term exposure to asensitizing allergen intensified the acuteness of inflammatory changes. The examinations were performedon patients with atopic diathesis who suffered from dyspepsia and gastralgia. The examined group included72 women between 16 and 57 years of age (mean age: 36.5 years) and 38 men from 16 to 60 years of age(mean age: 34.4 years). The control group included 40 patients with no traits of atopy (13 men and 27women between 18 and 56 years old, mean age: 34.8 years) with chronic gastritis confirmed by endoscopicand histopathological tests. All patients were subjected to endoscopy of the upper alimentary tract.Biopsy specimens were taken for histopathological analyses. They were stained with eosin and hematoxylin(the H&E method), and with a modified Giemsa method. The evaluation included the presence of chronicinflammation of gastric mucosa, its activity and intensity. The presence of H. pylori colonization wasdetermined with the use of histopathological method of staining. Significant differences were found concerninginflammation intensity in atopic patients additionally infected with H. pylori, in comparison with thegroup of patients with food allergy without bacterial colonization. The differences were found duringthe evaluation of mucosa of both the prepyloric area and body of the stomach (p < 0.001). Moreover, statisticallysignificant differences were found in the inflammation intensity between the examined group and the controlgroup with no symptoms of allergy. In atopic patients infected with Helicobacter pylori, a long-termexposure to food allergens increases the intensity of gastric mucosa inflammation.

Keywords: Adolescent, Biopsy, Chronic Disease, Comparative Study, Dyspepsia, Food Hypersensitivity, Gastric Mucosa, gastritis, Helicobacter Infections, Helicobacter pylori, Pyloric Antrum, Pylorus, Reference Values