Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 2005

Effective dose of 5-fluorouracil for myringotomy in rats.

Hakan Cincik, Hakan Cincik, Omer Saglam, Engin Cekin, Sükrü Yildirim, Ethem Poyrazoglu

Med Sci Monit 2005; 11(9): BR330-334 :: ID: 428444


Background: The purpose of this study is to compare the effects of twodifferent doses of 5-fluorouracil (5-FU) on closure rates and histopathological findings in myringotomyto those of simple myringotomy with saline application. Material/Methods: 36 rats were divided into twostudy groups and a control group of 12 rats each. After bilateral myringotomy, we applied 5-FU 50 mg/mlin group A, 10 mg/ml in group B and saline in the control group for 10 minutes. Examination was madeby otoendoscopy on days 1, 3, 5, 7, 10, 15, 20, 25. After the follow up examination, two rats from eachgroup were randomly sacrificed on days 7, 15, 25 and 35. Both tympanic membranes were investigated forfibrosis and inflammation by light microscopy. Results: Most of the tympanic membranes from group B andthe control group healed on the 10(th) day, but 16 myringotomies were patent in group A; by the 25(th)day, all myringotomies in all three groups were completely healed. The mean healing time was 14.62 days,10.20 days and 10.40 days respectively in groups A, B and control. Fibrosis and inflammation were lessin group A than in group B and the controls. Conclusions: 5-FU at a concentration of 50 mg/mL is effectivein prolonging the patency of myringotomies in rat tympanic membranes, while a concentration of 10 mg/mLhas no greater effect than a simple myringotomy procedure with saline application.

Keywords: Antimetabolites - administration & dosage, Dose-Response Relationship, Drug, Fibrosis, Fluorouracil - administration & dosage, Inflammation - prevention & control, Middle Ear Ventilation - methods, Otitis Media with Effusion - surgery, Tympanic Membrane - surgery, Wound Healing - drug effects

Add Comment 0 Comments

528 2


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209


In Press

07 Jun 2023 : Review article  

Ultrasound-Guided Brachial Plexus Block by Costoclavicular Space Approach: A Narrative Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939920  

05 Jun 2023 : Clinical Research  

Comparison of Texture and Color Enhancement Imaging with White Light Imaging in 52 Patients with Short-Segm...

Med Sci Monit In Press; DOI: 10.12659/MSM.940249  

05 Jun 2023 : Laboratory Research  

Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...

Med Sci Monit In Press; DOI: 10.12659/MSM.940949  

02 Jun 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750