Abstract

Background: An association between anticardiolipin antibodies and dementiahas been reported in several recent studies; however, its physiopathological mechanism remains controversial.The aim of this study was to evaluate the association of vascular dementia and anticardiolipin antibodies.Material/Methods: A random prospective investigation of 17 male and 13 female patients with vasculardementia was made with regard to anticardiolipin antibodies. Their ages ranged from 56 to 77 years (average:67.2 years). The criteria of NINDS-AIREN were used to define the vascular dementia. A control group of25 female and 9 male patients was formed with ages ranging from 62 to 80 years (mean: 68 years). Evaluationof the anticardiolipin antibodies was performed by means of Enzyme-Linked Immunoabsorbent Assay (ELISA)for the quantitative measurement of IgG and IgM antibodies against cardiolipins in serum. Statisticalanalysis was done using the Fisher's exact test, where p

Keywords: Antibodies, Anticardiolipin - blood, Case-Control Studies, Dementia, Vascular - immunology, Enzyme-Linked Immunosorbent Assay, Immunoglobulin G - blood, Immunoglobulin M - blood, Prospective Studies