01 September 2003
The role of oxidative stress in pathogenesis of asthma
Agnieszka Szlagatys, Maria KorzonMed Sci Monit 2003; 9(4): 89-93 :: ID: 428658
Abstract
There is a growing number of evidence indicating the oxidative stress involvement in pathogenesis of asthma. The overproduction of reactive oxygen species (ROS) is present in allergic inflammation. ROS may induce symptoms characteristic for asthma: bronchospasm, bronchial hyperresponsiveness, beta-adrenergic receptors ’dysfunction, mucus hypersecretion, activation of arachidonic acid cascade, increased permeablility and bronchial epithelial damage. The products of lipid and protein oxidative damage are increased in blood, BAL, and exhaled air of patients with asthma. There are also disorders in enzymatic and non-enzymatic components of antioxidative barrier in asthma. The antioxidative-prooxidative balance requires further research, yet it may contribute in understanding of pathogenesis of asthma. It may also have some therapeutic implication.
Keywords: oxidatise stress, Asthma
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952