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01 November 2005

The effects of topical estriol and vehicle cream on the mechanical and histological properties of normal rat skin

Irfan Ozyazgan, Narin Liman, Teoman Eskitaşçioğlu

Med Sci Monit 2005; 11(11): BR405-411 :: ID: 430290

Abstract

Background: The biomechanical and histological effects of topical estriol in normal rat skin are not clearly de-fi ned, although several favourable effects of estrogens have been suggested, especially in the postmenopausal period. Our goal was to determine whether estrogens have any such effects on skin histology and biomechanical properties in an experimental rat model.
Material/Methods: Estriol cream or vehicle cream was topically applied to the dorsum of Sprague Dawley rats of both genders in three separate groups for two weeks, and the results of the estriol and vehicle groups,as well as the non-treated control groups, were compared in terms of mechanical tensometric test
results and histopathological evaluation.
Results: After the application of topical estriol, histologically, subcutis thinned (p

Keywords: Elasticity, Estriol - pharmacology, Fibrillar Collagens - drug effects, Ointments, Pharmaceutical Vehicles, Skin - drug effects

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750