Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 October 2005

Ambulatory blood pressure, sympathetic activity, and left ventricular structureand function in middle-aged normotensive men with exaggerated blood pressure response to exercise.

Nobuyuki Miyai, Mikio Arita, Ikuharu Morioka, Shintaro Takeda, Kazuhisa Miyashita

Med Sci Monit 2005; 11(10): CR478-484 :: ID: 430309

Abstract

BACKGROUND: It is claimed that exaggerated blood pressure (BP) reactivityto behavioral stress may play a role in hypertension. This study aimed to clarify whether exaggeratedBP reactivity during physical exercise is associated with any other abnormalities in ambulatory BP, autonomicnervous control, and target organ damage among middle-aged normotensive men. MATERIAL/METHODS: A totalof 54 sedentary men (39+/-4 years old) with normal BP were enrolled in this study. Twenty-seven withexaggerated BP reactivity to exercise (ER) were compared with 27 age-matched controls with normal BPreactivity (NR). The subjects underwent 24-hour ambulatory BP monitoring, short-term Finapres recordings,a bicycle ergometry test, and M-mode and pulsed-Doppler echocardiography. RESULTS: The ambulatory BPmeasurements were significantly higher in the ER group than in the NR group averaged over a 24-hour period,during daytime and nighttime. Power spectral analysis from continuous Finapres data revealed increasedsystolic BP variability in the low frequency band in the ER group. During graded exercise, the ER groupshowed remarkable elevations in systolic and diastolic BP compared to the NR group without a differencein heart rate increments. Although the plasma epinephrine showed similar levels, yet the exercise-inducedincrease in plasma norepinephrine in the ER group was significantly greater than in the NR group. Inechocardiographic dimensions, left ventricular internal diameter and mass index were not different, whereasthe ER group presented significantly greater posterior wall thickness. Doppler functional data showedsignificant increase in the late to early flow velocity ratio in the ER group. CONCLUSIONS: Even in theabsence of hypertension, exaggerated BP reactivity to physical exercise suggests greater BP elevationduring daily activity as well as enhanced sympathetic nervous tonus, which may be considered a risk factorpromoting hypertension, and these hemodynamic and neurohumoral behaviors are associated with a tendencyto develop target organ abnormalities in the heart.

Keywords: Cross-Sectional Studies, Blood Pressure, Echocardiography, Exercise - physiology, Exercise Test, Heart Ventricles - anatomy & histology, Sympathetic Nervous System - physiology, Ventricular Function

0 Comments

Editorial

01 July 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937676

Med Sci Monit 2022; 28:e937676

SARS-CoV-2/COVID-19

27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

05 Jul 2022 : Clinical Research  

Attention-Deficit/Hyperactivity Disorder (ADHD) and Time Perception in Adults: Do Adults with Different ADH...

Med Sci Monit In Press; DOI: 10.12659/MSM.936849  

01 Jul 2022 : Clinical Research  

Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?

Med Sci Monit In Press; DOI: 10.12659/MSM.936792  

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750