Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 2005

The expression of vWF receptor on newborn platelets.

Alicja Wasiluk

Med Sci Monit 2005; 11(11): CR545-548 :: ID: 430370

Abstract

Background: Platelets contain a complex known as GPIb-IX-V. The receptorfor vWF is located in GPIba. The number of functional receptors decreases during thrombin activationof platelets. This study was performed to evaluate the percentage of platelets displaying the GPIbalpha-IX complex on their surface Material/Methods: We studied 51 healthy term newborns (21 females and 30males). Blood was collected from the umbilical artery and vein immediately after severance of the umbilicalcord, using a Diatube TM CTAD Vacutainer System. The GPIbalpha-IX complex was tested with CD42b-PE antibody,using a EPICS XL flow cytometer. Results: Practically no differences were observed in the percentageof platelets demonstrating CD42b in venous blood (18.59%) and arterial blood (19.37%). The percentageof platelets bearing the CD42b molecule is higher in male newborns (20.58%) than female (17.38%). Healthycontrol adults demonstrated an increased percentage of CD42b on platelets (30.4%) in comparison to newborns(18.98%). Conclusions: The sex of neonates affects the tested complex: higher values were noted in males.The particular umbilical vessel (vein or artery) has no effect on the percentage of platelets bearingCD42b.

Keywords: Blood Platelets - metabolism, Fetal Blood - cytology, Infant, Newborn, Platelet Glycoprotein GPIb-IX Complex - metabolism, Platelet Membrane Glycoproteins - metabolism, Receptors, Cell Surface - metabolism, Sex Factors

Add Comment 0 Comments

556 6

Editorial

01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960

0:00

In Press

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Impact of COVID-19 on Academic Burnout among Medical College Students in China: Findings from a Web-Based S...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750