Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 2005

Anaplastic carcinoma of the pancreas with squamous features: report of a case and immunohistochemical study.

Hirozumi Sawai, Yuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Hiromitsu Takeyama, Tadao Manabe

Med Sci Monit 2005; 11(11): CS65-68 :: ID: 430398


Background: Anaplastic carcinomas of the pancreas are rare aggressive tumorswith survival measurable in weeks. Many terms have been applied used to describe these tumors, and anaplasticfoci are identified in ductal adenocarcinomas and in ectopic pancreata, but are not the dominant patternof growth. We herein present our experience with a case of anaplastic carcinoma of the pancreas withsquamous features in order that allowed us to delineate the clinicopathologic and immunohistochemicalfeatures of this rare entity. Case Report: According to imaging findings, the 77-year-old Japanese manwas diagnosed as the malignant pancreatic tumor, and underwent a surgical resection. Histopathologically,anaplastic tumor cells showed focal ductal and squamous features infiltrated into pancreatic parenchyma,extrapancreatic fatty tissue, and stomach. The tumor cells showed strong reactivity for cytokeratin,alpha-SMA, vimentin, NSE, and S-100 protein. Although immunoreactivity against p53 was negative, strongpositive immunostaining for proliferating cell nuclear antigen and interleukin-1 receptor type I (IL-1RI)was observed in a the majority of tumor cells, while the alpha(6) integrin subunit was predominantlystrong expressed in the adenocarcinomatous lesion. The patient's postoperative course was uneventfuland he was treated with a chemotherapy consisting of gemcitabine. After discharging from the hospital,he had subsequently been observed as an outpatient and same chemotherapy was followed by weekly. However,the patient suffered from peritonitis carcinomatosa and re-increases of multiple liver metastases, andhe died in the fourteenth month after surgery. Conclusions: Our immunohistochemical studies suggestedthat the prognosis of the case with anaplastic carcinoma presented here would be poor, due to the strongexpression of integrins and IL-1RI.

Keywords: Carcinoma, Squamous Cell - diagnosis, Carcinoma - surgery, Fatal Outcome, Integrins - analysis, Pancreatic Neoplasms - surgery, Peritoneal Neoplasms - secondary, Receptors, Interleukin-1 - analysis, Tumor Markers, Biological - analysis

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Animal Research  

Curcumin as a Potential Therapeutic Agent for Mitigating Carbon Monoxide Poisoning: Evidence from an Experi...

Med Sci Monit In Press; DOI: 10.12659/MSM.943739  

Animal Research  

Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944185  

Review article  

A New Pandemic of the XXIst Century: The Growing Crisis of Adolescent Depression in the Digital Age

Med Sci Monit In Press; DOI: 10.12659/MSM.944838  

Review article  

A Review of Wastewater-Based Epidemiology Studies for the Assessment of Over-the-Counter Medicines Used as ...

Med Sci Monit In Press; DOI: 10.12659/MSM.944120  

Most Viewed Current Articles

17 Jan 2024 : Review article   1,652,499

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,522,350

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   690,265

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,215

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750