01 December 2005
Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat.Costantine Daher, Jamil Abou-Khalil, George Baroody
Med Sci Monit 2005; 11(12): BR465-472 :: ID: 438850
Background: High fruit intake is known to be associated with reduced riskof coronary heart disease. Our objective was to determine the effects of acute and chronic juice [grapefruit,orange, and pineapple] intake on plasma lipid profile and lipoprotein metabolism in normolipidemic rats.Material/Methods: The effects of acute juice intake were studied after three hours of a single juice-lipidload instilled intragastrically. In the chronic study, blood samples from fasted animals were subjectedto analyses after six months of either water [control] or water-juice [1:1] intake. Results: In the acutestudy, pineapple and grapefruit significantly decreased plasma triacylglycerol [TAG], and chylomicron[CM] TAG and cholesterol concentrations concomitantly with delayed gastric emptying. Plasma cholesterollevels and very-low-density lipoprotein [VLDL] secretion and metabolism were not affected. In the chronicstudy, only grapefruit significantly decreased plasma and VLDL TAG concentrations and relative VLDL particlesize with respect to other groups. All juices significantly increased VLDL apolipoprotein B [apoB] secretion,but plasma total apoB concentrations were highest in the grapefruit group and lowest in the orange andpineapple groups. No effect on blood cholesterol levels was observed. Conclusions: The cardioprotectivebenefit of chronic juice intake in normolipidemic rat may be chiefly through mechanisms independent ofa direct effect on blood lipid profile, although orange and pineapple, but not grapefruit, relativelyimproved the metabolism and clearance of blood lipoprotein particles. As a result of delayed gastricemptying, grapefruit and pineapple juices may moderate sharp increases in postprandial plasma TAG concentrationsaccompanying peak digestion and absorption.
Keywords: Beverages, Ananas - chemistry, Citrus paradisi - chemistry, Citrus sinensis - chemistry, Drinking, Lipids - blood
01 February 2023 : EditorialEditorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread
Med Sci Monit 2023; 29:e939580
19 January 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
03 Feb 2023 : Clinical ResearchTreatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...
Med Sci Monit In Press; DOI: 10.12659/MSM.938865
02 Feb 2023 : Clinical ResearchOnline Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...
Med Sci Monit In Press; DOI: 10.12659/MSM.938672
02 Feb 2023 : Database AnalysisPrognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based...
Med Sci Monit In Press; DOI: 10.12659/MSM.938785
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292