Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 December 2005

IgG subclass antibody response to mycobacterial serine protease at differentstages of pulmonary tuberculosis.

Sonika Gupta, Niraj Shende, Amarjeet Bhatia, Satish Kumar, Bhaskar Harinath

Med Sci Monit 2005; 11(12): CR585-588 :: ID: 438856

Abstract

Background: Tuberculosis (TB) is a chronic bacterial infection caused by M. Tuberculosis. Studies of antibody response in TB have focussed mainly on their usefulness as a diagnosticserological tool, with little attention given to analysis of antibodies at the isotype and subclass levelin relation to disease pathogenesis. Hence the present study was done to analyse IgG subclass responseat different stages of tuberculosis, in order to understand the immunological events associated withdisease development. Material/Methods: Sera samples were collected from 104 subjects: 79 tuberculosispatients (fresh, relapse and chronic cases) and 25 healthy normals. IgG subclass antibody response wasanalysed by indirect plate peroxidase ELISA against previously reported mycobacterial serine protease(ES-31) antigen. Results: Fresh cases of tuberculosis showed increased IgG1 and IgG3 antibodies, whilea few cases showed moderately increased IgG2. IgG1 and IgG3 were found to be elevated with increasedbacillary load. Relapse and chronic cases showed increased IgG1 and IgG3, while positivity to IgG2 wasdecreased. Chronic cases showed a moderate increase in IgG4 antibody. Thus IgG1 and IgG3 were predominantin all forms of tuberculosis. Conclusions: The elevated levels of IgG1 and IgG3 antibodies to mycobacterialserine protease in active tuberculosis observed in this study provide an additional marker for diagnosisof tuberculosis. Furthermore, the higher level of these antibodies with high bacillary load patientsand in chronic cases of tuberculosis may provide valuable insight into their possible role in diseaseprogression.

Keywords: Antibody Formation, Antibodies, Bacterial - blood, Biological Markers, Disease Progression, Immunoglobulin G - blood, Mycobacterium tuberculosis - immunology, Serine Endopeptidases - immunology, Tuberculosis, Pulmonary - diagnosis

Add Comment 0 Comments

713 15

Editorial

01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

0:00

In Press

31 May 2023 : Review article  

Prevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939919  

30 May 2023 : Clinical Research  

A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...

Med Sci Monit In Press; DOI: 10.12659/MSM.940409  

30 May 2023 : Review article  

A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...

Med Sci Monit In Press; DOI: 10.12659/MSM.940550  

30 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750