01 December 2005
Influence of systemic photochemotherapy on regulatory T cells and selected cytokine production in psoriatic patients: a pilot study.
Anna Zalewska, Ewa Trznadel-Budźko, Przemysław Lewkowicz, Małgorzata Banasik, Henryk Tchórzewski, Ewa GłowackaMed Sci Monit 2005; 11(12): CR594-598 :: ID: 438858
Abstract
Background: Psoriasis is a chronic autoimmune inflammatory disease of theskin with strong genetic and environmental risk factors and is regarded as a Th1 cell-type disease. Theaim of our study was to evaluate the effect of one-month PUVA (Psoralen Ultraviolet A) therapy on a regulatoryT-cell subpopulation (CD4+CD25+) and the production of some cytokines. Material/Methods: The study wasperformed on the group of 12 patients with severe psoriasis. They were put on PUVA therapy for one month.We analyzed the level of CD4+CD25+ regulatory T cells using a FACSCalibur cytometer and CellQuest Software.The production of IFN-gamma (interferon-gamma), TNF-alpha (tumor necrosis factor alpha), IL (interleukin)-10, IL-5, IL-4, and IL-2 by lymphocytes was estimated by using a CBA system. The control group consistedof 11 healthy volunteers. Results: We found that the production of INF-gamma, TNF-alpha, IL-2, and IL-10in psoriatic patients before PUVA application increased significantly compared with the control group.In patients after PUVA therapy we observed decreased production of TNF-alpha and a decreased number ofCD4+CD25+ cells in the blood compared with the same group of patients before the treatment. Conclusions:It was demonstrated that systemic PUVA therapy led to a marked reduction in CD4+CD25+ T cells and a changein cytokine production.
Keywords: Cytokines - biosynthesis, PUVA Therapy, Pilot Projects, Psoriasis - immunology, T-Lymphocytes, Regulatory - immunology
827 2
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
30 Nov 2023 : Clinical Research
Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...Med Sci Monit In Press; DOI:
29 Nov 2023 : Clinical Research
Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...Med Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292