01 December 2005
Intravenous Foscarnet in the Management of Acyclovir-Resistant Herpes Simplex Virus Type 2 in Acute Retinal Necrosis in Children
Alexander Charonis, Michael A Samuel, Anurag Gupta, Khaled A TawansyMed Sci Monit 2005; 11(12): CS75-78 :: ID: 438860
Abstract
Background: Diagnosis and management of Acute Retinal Necrosis (ARN) inchildren that does not respond to systemic acyclovir treatment can be challenging. We report two casesof ARN secondary to herpes simplex virus (HSV) type 2 that was resistant to acyclovir but was treatedsuccessfully with intravenous foscarnet. Case Report: Two children diagnosed with ARN failed to showclinical response to systemic acyclovir treatment. Both cases had histories of previous HSV infectionsand vitreous taps positive for HSV-2. Both were converted to systemic foscarnet treatment with successfulcontrol of the retinitis and satisfactory visual outcomes. Conclusions: Systemic foscarnet can be effectivein the management of pediatric acute retinal necrosis caused by HSV-2 when there is an atypical responseto conventional acyclovir treatment.
Keywords: Child, Antiviral Agents - therapeutic use, Adolescent, Acyclovir - therapeutic use, Drug Resistance, Viral, Foscarnet - therapeutic use, Herpes Simplex - virology, Herpesvirus 2, Human - drug effects, Injections, Intravenous, Retinal Necrosis Syndrome, Acute - virology
937 27
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
30 Nov 2023 : Clinical Research
Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...Med Sci Monit In Press; DOI:
29 Nov 2023 : Clinical Research
Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...Med Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292